ZNF274

ZNF274
Identifiers
Aliases	ZNF274, HFB101, ZF2, ZKSCAN19, ZSCAN51, zinc finger protein 274
External IDs	OMIM: 605467 MGI: 2176229 HomoloGene: 129707 GeneCards: ZNF274
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.43 Start 58,183,029 bp End 58,213,562 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 B3 Start 65,426,628 bp End 65,452,035 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland sural nerve right ventricle retinal pigment epithelium left ventricle right uterine tube cerebellar hemisphere lactiferous duct Achilles tendon Top expressed in retinal pigment epithelium ciliary body thymus primitive streak fossa ascending aorta iris ganglionic eminence superior frontal gyrus aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding transcription corepressor activity metal ion binding nucleic acid binding chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleolus intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of histone H3-K9 trimethylation negative regulation of nucleic acid-templated transcription regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10782 170936 Ensembl ENSG00000171606 ENSMUSG00000021514 UniProt Q96GC6 Q921B4 RefSeq (mRNA) NM_001278734 NM_001278735 NM_016324 NM_016325 NM_133502 NM_178364 RefSeq (protein) NP_001265663 NP_057408 NP_057409 NP_598009 n/a Location (UCSC) Chr 19: 58.18 – 58.21 Mb Chr 13: 65.43 – 65.45 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.

This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Petroni D, Bartolini E, Chiaramonte R, et al. (1999). "Computer sequence analysis of human highly conserved zinc finger modules". DNA Seq. 9 (3): 163–9. doi:10.3109/10425179809072191. PMID 10520746.
• Casademunt E, Carter BD, Benzel I, et al. (2000). "The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death". EMBO J. 18 (21): 6050–61. doi:10.1093/emboj/18.21.6050. PMC 1171670. PMID 10545116.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Sripathy SP, Stevens J, Schultz DC (2007). "The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression". Mol. Cell. Biol. 26 (22): 8623–38. doi:10.1128/MCB.00487-06. PMC 1636786. PMID 16954381.

External links

• ZNF274+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ZNF274

This article incorporates text from the United States National Library of Medicine, which is in the public domain.