Nozomi Nishimura

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Nozomi Nishimura
Born
Tucson
Alma materUniversity of California, San Diego
Harvard College
Scientific career
InstitutionsCornell University
ThesisMicrovascular lesions and blood flow in rodent cortex (2006)
Academic advisorsEric Mazur

Nozomi Nishimura is an American biomedical engineer who is an associate professor at Cornell University. She was awarded the L'Oréal for Women in Science Fellowship in 2009.

Early life and education[edit]

Nishimura grew up in Tucson, Arizona.[1] She studied physics at Harvard College, where she worked alongside Eric Mazur on femtosecond laser ablation.[citation needed] She was a graduate student in physics at the University of California, San Diego, where she became interested in neuroscience.[2] She studied blood flow in the brains of rodents and developed models of stroke.[3] To study these mini-strokes she used a tightly focused laser light to excite a dye that had been injected into the bloodstream.[4] In 2006, she moved to Cornell University, where was made a National Institutes of Health and American Heart Association Fellow.[citation needed]

Research and career[edit]

Nishimura was appointed to the faculty at Cornell in 2013, where she develops in vivo imaging techniques to study neurodegenerative disease and cancer metastasis. She uses transient multi-photon microscopy to understand cellular dynamics, and femtosecond laser ablation to understand cellular function.[5][6] In particular, Nishimura showed that two photon excited fluorescence could be used to image individual cells and capillaries.[7] Changes in blood flow influences the progression of disease. For example, Nishimura demonstrated that in mouse models of Alzheimer's disease impeded blood flow in the brain due to neutrophils plugging capillaries, impacting total blood flow.[8]

Awards and honors[edit]

  • 2009 L'Oréal USA Fellowship for Women in Science[9]

Selected publications[edit]

  • Demirhan Kobat; Michael E Durst; Nozomi Nishimura; Angela W Wong; Chris B Schaffer; Chris Xu (1 August 2009). "Deep tissue multiphoton microscopy using longer wavelength excitation". Optics Express. 17 (16): 13354–13364. doi:10.1364/OE.17.013354. ISSN 1094-4087. PMID 19654740. Wikidata Q48494423.
  • Andy Y Shih; Jonathan D Driscoll; Patrick J Drew; Nozomi Nishimura; Chris B Schaffer; David Kleinfeld (February 2013). "Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain". Journal of Cerebral Blood Flow & Metabolism. 33 (2): 319–319. doi:10.1038/JCBFM.2012.177. ISSN 0271-678X. PMC 3564205. Wikidata Q62556738.
  • Dimitre G Ouzounov; Tianyu Wang; Mengran Wang; et al. (20 February 2017). "In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain". Nature Methods. 14 (4): 388–390. doi:10.1038/NMETH.4183. ISSN 1548-7091. PMC 6441362. PMID 28218900. Wikidata Q48300624.

References[edit]

  1. ^ "Nozomi Nishimura | Meinig School of Biomedical Engineering". www.bme.cornell.edu. Retrieved 2024-01-21.
  2. ^ "Nozomi Nishimura, Ph. D. – Beckman Laser Institute". Retrieved 2024-01-22.
  3. ^ "Nozomi Nishimura | Cornell Engineering". www.engineering.cornell.edu. Retrieved 2024-01-22.
  4. ^ "UCSD laser technique sheds light on strokes". EurekAlert!. Retrieved 2024-01-22.
  5. ^ "Biomedical engineering symposium showcases research, facilitates collaborations | Cornell Chronicle". news.cornell.edu. Retrieved 2024-01-21.
  6. ^ "Schaffer-Nishimura Lab". snlab.bme.cornell.edu. Retrieved 2024-01-21.
  7. ^ "Real-time imaging of stroke models". ScienceDaily. Retrieved 2024-01-22.
  8. ^ Cruz Hernández, Jean C.; Bracko, Oliver; Kersbergen, Calvin J.; Muse, Victorine; Haft-Javaherian, Mohammad; Berg, Maxime; Park, Laibaik; Vinarcsik, Lindsay K.; Ivasyk, Iryna; Rivera, Daniel A.; Kang, Yiming; Cortes-Canteli, Marta; Peyrounette, Myriam; Doyeux, Vincent; Smith, Amy (March 2019). "Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models". Nature Neuroscience. 22 (3): 413–420. doi:10.1038/s41593-018-0329-4. ISSN 1546-1726. PMC 6508667. PMID 30742116.
  9. ^ "Changing the Face of STEM". www.loreal.com. Retrieved 2024-01-21.
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