From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene .[5] [6]
The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1 . PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation . Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000156374 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025050 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF) . Genes Cells . 7 (8): 835–50. doi :10.1046/j.1365-2443.2002.00565.x . hdl :2027.42/72663 PMID 12167161 . S2CID 23060582 . ^ a b "Entrez Gene: PCGF6 polycomb group ring finger 6" .
Further reading [ edit ]
Kanno M, Hasegawa M, Ishida A, et al. (1996). "mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity" . EMBO J . 14 (22): 5672–8. doi :10.1002/j.1460-2075.1995.tb00254.x . PMC 394682 PMID 8521824 . Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1519–24. doi :10.1073/pnas.041597698 PMC 29289 PMID 11171983 . Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development . 129 (18): 4171–83. doi :10.1242/dev.129.18.4171 . PMID 12183370 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81. Bibcode :2004Natur.429..375D . doi :10.1038/nature02462 PMID 15164054 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Zhong N, Radu G, Ju W, Brown WT (2006). "Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C". Biochem. Biophys. Res. Commun . 338 (2): 855–61. doi :10.1016/j.bbrc.2005.10.020 . PMID 16248985 . Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein" . Cell . 128 (5): 877–87. doi :10.1016/j.cell.2007.02.004 PMID 17320162 . S2CID 6519228 .
