Serine protease 57
| PRSS57 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PRSS57, PRSSL1, UNQ782, NSP4, protease, serine 57, serine protease 57 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1920356 HomoloGene: 133812 GeneCards: PRSS57 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Serine protease 57 is a protein that in humans is encoded by the PRSS57 gene. [5]
Function[edit]
This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016].
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185198 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020323 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Serine protease 57". Retrieved 2018-08-19.
Further reading[edit]
- Perera NC, Wiesmüller KH, Larsen MT, Schacher B, Eickholz P, Borregaard N, Jenne DE (September 2013). "NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity". J. Immunol. 191 (5): 2700–7. doi:10.4049/jimmunol.1301293. PMID 23904161.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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