Time-resolved mass spectrometry
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Time-resolved mass spectrometry (TRMS) is a strategy in analytical chemistry that uses mass spectrometry platform to collect data with temporal resolution.[1][2][3] Implementation of TRMS builds on the ability of mass spectrometers to process ions within sub-second duty cycles. It often requires the use of customized experimental setups. However, they can normally incorporate commercial mass spectrometers. As a concept in analytical chemistry, TRMS encompasses instrumental developments (e.g. interfaces, ion sources, mass analyzers), methodological developments, and applications.
Applications[edit]
An early application of TRMS was in the observation of flash photolysis process.[4] It took advantage of a time-of-flight mass analyzer.[5] TRMS currently finds applications in the monitoring of organic reactions,[6] formation of reactive intermediates,[7] enzyme-catalyzed reactions,[8] convection,[9] protein folding,[10] extraction,[11] and other chemical and physical processes.
Temporal resolution[edit]
TRMS is typically implemented to monitor processes that occur on second to millisecond time scale. However, there exist reports from studies in which sub-millisecond resolutions were achieved.[4][5][6]
References[edit]
- ^ Urban P.L., Chen Y.-C., Wang Y.-S. 2016, Time-Resolved Mass Spectrometry: From Concept to Applications. Wiley, Chichester, ISBN 978-1-118-88732-5, http://as.wiley.com/WileyCDA/WileyTitle/productCd-1118887328.html
- ^ Chen, Yu-Chie; Urban, Pawel L. (2013). "Time-resolved mass spectrometry". TrAC Trends in Analytical Chemistry. 44: 106–20. doi:10.1016/j.trac.2012.11.010.
- ^ Rob, Tamanna; Wilson, Derek (2012). "Time-resolved mass spectrometry for monitoring millisecond time-scale solution-phase processes". European Journal of Mass Spectrometry. 18 (2): 205–14. doi:10.1255/ejms.1176. PMID 22641726. S2CID 25038189.
- ^ a b Meyer, Richard T. (1967). "Flash Photolysis and Time‐Resolved Mass Spectrometry. I. Detection of the Hydroxyl Radical". The Journal of Chemical Physics. 46 (3): 967–972. Bibcode:1967JChPh..46..967M. doi:10.1063/1.1840834.
- ^ a b "Apparatus for flash photolysis and time resolved mass spectrometry". Retrieved 27 January 2014.
- ^ a b Miao, Zhixin; Chen, Hao; Liu, Pengyuan; Liu, Yan (2011). "Development of Submillisecond Time-Resolved Mass Spectrometry Using Desorption Electrospray Ionization". Analytical Chemistry. 83 (11): 3994–7. doi:10.1021/ac200842e. PMID 21539335. S2CID 5294644.
- ^ Perry, Richard H.; Splendore, Maurizio; Chien, Allis; Davis, Nick K.; Zare, Richard N. (2011). "Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization". Angewandte Chemie International Edition. 50 (1): 250–4. doi:10.1002/anie.201004861. PMID 21110361. S2CID 205360159.
- ^ Ting, Hsu; Urban, Pawel L. (2014). "Spatiotemporal effects of a bioautocatalytic chemical wave revealed by time-resolved mass spectrometry". RSC Advances. 4 (5): 2103–8. Bibcode:2014RSCAd...4.2103T. doi:10.1039/C3RA42873G. S2CID 93801916.
- ^ Li, Po-Han; Ting, Hsu; Chen, Yu-Chie; Urban, Pawel L. (2012). "Recording temporal characteristics of convection currents by continuous and segmented-flow sampling" (PDF). RSC Advances. 2 (32): 12431–7. Bibcode:2012RSCAd...212431L. doi:10.1039/C2RA21695G.
- ^ Breuker, K.; McLafferty, F. W. (2008). "Stepwise evolution of protein native structure with electrospray into the gas phase, 10-12 to 102 s". Proceedings of the National Academy of Sciences. 105 (47): 18145–52. Bibcode:2008PNAS..10518145B. doi:10.1073/pnas.0807005105. JSTOR 25465429. PMC 2587555. PMID 19033474.
- ^ Hu, J.-B.; Chen, S.-Y.; Wu, J.-T.; Chen, Y.-C.; Urban, P L. (2014). "Automated system for extraction and instantaneous analysis of millimeter-sized samples". RSC Advances. 4 (21): 10693–10701. Bibcode:2014RSCAd...410693H. doi:10.1039/C3RA48023B. S2CID 44124259.