PHPT1

PHPT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AI6, 2HW4, 2NMM, 2OZW, 2OZX
Identifiers
Aliases	PHPT1, CGI-202, HEL-S-132P, HSPC141, PHP14, phosphohistidine phosphatase 1, PHP
External IDs	OMIM: 610167 MGI: 1922704 HomoloGene: 8573 GeneCards: PHPT1
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 136,848,724 bp End 136,851,027 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 25,463,442 bp End 25,465,236 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right adrenal gland body of pancreas right lobe of thyroid gland right uterine tube gastrocnemius muscle left lobe of thyroid gland cingulate gyrus Brodmann area 9 left coronary artery Top expressed in lens yolk sac quadriceps femoris muscle neural tube cerebellum olfactory bulb muscle tissue cerebellar cortex skeletal muscle tissue ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel inhibitor activity phosphoprotein phosphatase activity hydrolase activity transmembrane transporter binding protein binding protein histidine phosphatase activity Cellular component cytoplasm cytosol extracellular exosome Biological process negative regulation of lyase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus protein dephosphorylation regulation of actin cytoskeleton reorganization peptidyl-histidine dephosphorylation negative regulation of ATP citrate synthase activity positive regulation of cell motility negative regulation of T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29085 75454 Ensembl ENSG00000054148 ENSMUSG00000036504 UniProt Q9NRX4 Q9DAK9 RefSeq (mRNA) NM_001135860 NM_001135861 NM_001287342 NM_001287343 NM_014172 NM_029293 RefSeq (protein) NP_001129333 NP_001274271 NP_001274272 NP_054891 NP_083569 Location (UCSC) Chr 9: 136.85 – 136.85 Mb Chr 2: 25.46 – 25.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

14 kDa phosphohistidine phosphatase is an enzyme that in humans is encoded by the PHPT1 gene.

Further reading

• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Lai CH, Chiu JY, Lin W (2001). "Identification of the human crooked neck gene by comparative gene identification". Biochim. Biophys. Acta. 1517 (3): 449–54. doi:10.1016/s0167-4781(00)00295-5. PMID 11342225.
• Ek P, Pettersson G, Ek B, et al. (2002). "Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase". Eur. J. Biochem. 269 (20): 5016–23. doi:10.1046/j.1432-1033.2002.03206.x. PMID 12383260.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ma R, Kanders E, Sundh UB, et al. (2005). "Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity". Biochem. Biophys. Res. Commun. 337 (3): 887–91. doi:10.1016/j.bbrc.2005.09.134. PMID 16219293.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.