MAP1S

MAP1S
Identifiers
Aliases	MAP1S, BPY2IP1, C19orf5, MAP8, VCY2IP-1, VCY2IP1, microtubule associated protein 1S
External IDs	OMIM: 607573 MGI: 2443304 HomoloGene: 10047 GeneCards: MAP1S
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,734,513 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,370,173 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; stromal cell of endometrium; ; putamen; ; amygdala; ; ganglionic eminence; ; caudate nucleus; ; nucleus accumbens; ; gallbladder; ; anterior pituitary;
	Top expressed in
	yolk sac; ; superior frontal gyrus; ; internal carotid artery; ; ankle joint; ; entorhinal cortex; ; external carotid artery; ; neural tube; ; thymus; ; somite; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; deoxyribonuclease activity; microtubule binding; tubulin binding; actin filament binding; protein binding; beta-tubulin binding; identical protein binding; actin binding;
Cellular component	cytosol; cell projection; microtubule cytoskeleton; spindle; synapse; cell junction; neuronal cell body; dendrite; nucleolus; perinuclear region of cytoplasm; microtubule; cytoskeleton; nucleus; cytoplasm; microtubule associated complex;
Biological process	neuron projection morphogenesis; nervous system development; autophagy; brain development; microtubule bundle formation; mitochondrion transport along microtubule; microtubule cytoskeleton organization; apoptotic process; DNA metabolic process; axonogenesis; dendrite development; regulation of microtubule depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	55201
	270058
	ENSG00000130479
	ENSMUSG00000019261
	Q66K74
	Q8C052
	NM_001308363; NM_018174
	NM_173013
	NP_001295292; NP_060644
	NP_766601
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene.^[5]^[6]^[7]^[8]^[9]

Interactions[edit]

MAP1S has been shown to interact with RASSF1.^[10]^[11]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130479 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019261 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu L, McKeehan WL (Feb 2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999. PMID 11827465.
^ Orbán-Németh Z, Simader H, Badurek S, Tranciková A, Propst F (Jan 2005). "Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family". J. Biol. Chem. 280 (3): 2257–65. doi:10.1074/jbc.M408984200. PMID 15528209.
^ Ding J, Valle A, Allen E, Wang W, Nardine T, Zhang Y, Peng L, Yang Y (January 2006). "Microtubule-associated protein 8 contains two microtubule binding sites". Biochem. Biophys. Res. Commun. 339 (1): 172–9. doi:10.1016/j.bbrc.2005.10.199. PMID 16297881.
^ Wong EY, Tse JY, Yao KM, Lui VC, Tam PC, Yeung WS (Feb 2004). "Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein". Biol. Reprod. 70 (3): 775–84. doi:10.1095/biolreprod.103.018531. PMID 14627543.
^ "Entrez Gene: MAP1S microtubule-associated protein 1S".
^ Liu L, Vo A, McKeehan WL (Mar 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
^ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

Further reading[edit]

Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Liu L, Vo A, McKeehan WL (2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
Liu L, Vo A, Liu G, McKeehan WL (2005). "Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein". Biochem. Biophys. Res. Commun. 332 (3): 670–6. doi:10.1016/j.bbrc.2005.05.006. PMC 3225229. PMID 15907802.
Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130479 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019261 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11827465-5] Liu L, McKeehan WL (Feb 2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999. PMID 11827465.

[pmid15528209-6] Orbán-Németh Z, Simader H, Badurek S, Tranciková A, Propst F (Jan 2005). "Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family". J. Biol. Chem. 280 (3): 2257–65. doi:10.1074/jbc.M408984200. PMID 15528209.

[pmid16297881-7] Ding J, Valle A, Allen E, Wang W, Nardine T, Zhang Y, Peng L, Yang Y (January 2006). "Microtubule-associated protein 8 contains two microtubule binding sites". Biochem. Biophys. Res. Commun. 339 (1): 172–9. doi:10.1016/j.bbrc.2005.10.199. PMID 16297881.

[pmid14627543-8] Wong EY, Tse JY, Yao KM, Lui VC, Tam PC, Yeung WS (Feb 2004). "Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein". Biol. Reprod. 70 (3): 775–84. doi:10.1095/biolreprod.103.018531. PMID 14627543.

[entrez-9] "Entrez Gene: MAP1S microtubule-associated protein 1S".

[pmid15753381-10] Liu L, Vo A, McKeehan WL (Mar 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.

[pmid15205320-11] Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

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