Motoric cognitive risk
Motoric cognitive risk (MCR) is a syndrome that has been defined as a pre-dementia state.[1] It is characterized by a measurable slow walking speed and self-reported cognitive complaints in the absence of significant functional impairment or dementia.[1] The cognitive impairment is less than what would typically be detected on standard cognitive testing. The syndrome was first introduced by J. Verghese et al. in 2013.[1]
MCR has been shown to reliably identify individuals at high risk.[2] MCR has potential for early identification and prevention of dementia.
Diagnosis[edit]
In the context of MCR, slow gait speed is defined as being one standard deviation below the age and sex-matched average for that population.[1] Self-reported cognitive complaints have been measured differently in various studies.[1]
References[edit]
- ^ a b c d e Verghese J, Wang C, Lipton RB, Holtzer R. Motoric cognitive risk syndrome and the risk of dementia. Journals Gerontol - Ser A Biol Sci Med Sci. 2013;68(4):412-418. doi:10.1093/gerona/gls191
- ^ Mullin DS, Cockburn A, Welstead M, Luciano M, Russ TC, Muniz‐Terrera G. Mechanisms of motoric cognitive risk—Hypotheses based on a systematic review and meta‐analysis of longitudinal cohort studies of older adults. Alzheimer’s Dement. Published online February 9, 2022. doi:10.1002/ALZ.12547