Fucosyltransferase 4

FUT4
Identifiers
Aliases	FUT4, CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1, fucosyltransferase 4
External IDs	OMIM: 104230 MGI: 95594 HomoloGene: 1538 GeneCards: FUT4
Gene location (Human) Chr. Chromosome 11 (human) Band 11q21 Start 94,543,921 bp End 94,549,895 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A2|9 4.3 cM Start 14,659,616 bp End 14,663,689 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow trabecular bone monocyte bone marrow cells jejunal mucosa duodenum rectum tibia islet of Langerhans appendix Top expressed in left colon Paneth cell epithelium of stomach duodenum seminal vesicula jejunum conjunctival fornix ileum intestinal villus left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity fucosyltransferase activity glycosyltransferase activity alpha-(1->3)-fucosyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane cell surface Golgi apparatus membrane cell periphery Golgi membrane Biological process protein glycosylation fucosylation L-fucose catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2526 14345 Ensembl ENSG00000196371 ENSMUSG00000049307 UniProt P22083 Q11127 RefSeq (mRNA) NM_002033 NM_010242 RefSeq (protein) NP_002024 NP_034372 Location (UCSC) Chr 11: 94.54 – 94.55 Mb Chr 9: 14.66 – 14.66 Mb PubMed search
Wikidata
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Fucosyltransferase 4 is a protein that in humans is encoded by the FUT4 gene.

Function

The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009].

Further reading

• Barry SM, Zisoulis DG, Neal JW, Clipstone NA, Kansas GS (September 2003). "Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells". Blood. 102 (5): 1771–8. doi:10.1182/blood-2002-11-3551. PMID 12738675.
• Azuma Y, Ito M, Taniguchi A, Matsumoto K (June 2004). "Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis". Biochim. Biophys. Acta. 1672 (3): 157–63. doi:10.1016/j.bbagen.2004.03.006. PMID 15182935.
• Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M, Spertini O (February 2005). "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII". J. Biol. Chem. 280 (7): 5378–90. doi:10.1074/jbc.M410899200. PMID 15579466.
• Higai K, Ichikawa A, Matsumoto K (September 2006). "Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein". Biochim. Biophys. Acta. 1760 (9): 1355–63. doi:10.1016/j.bbagen.2006.03.015. PMID 16842926.
• Azuma Y, Kurusu Y, Sato H, Higai K, Matsumoto K (April 2007). "Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis". Biol. Pharm. Bull. 30 (4): 655–60. doi:10.1248/bpb.30.655. PMID 17409497.
• Yang X, Zhang Z, Jia S, Liu Y, Wang X, Yan Q (2007). "Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation". Int. J. Biochem. Cell Biol. 39 (9): 1722–30. doi:10.1016/j.biocel.2007.04.024. PMID 17556010.
• Cruse JM, Lewis RE, Sanders CM, Webb RN, Beason KL, Lam J, Koehler J (October 2007). "Diminished CD10, CD13, and CD15 expression in a differentiated granulocyte population in CML". Exp. Mol. Pathol. 83 (2): 274–6. doi:10.1016/j.yexmp.2007.05.005. PMID 17662271.
• Zhang Z, Sun P, Liu J, Fu L, Yan J, Liu Y, Yu L, Wang X, Yan Q (February 2008). "Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth". Biochim. Biophys. Acta. 1783 (2): 287–96. doi:10.1016/j.bbamcr.2007.10.007. PMID 18023290.
• Plesa C, Chelghoum Y, Plesa A, Elhamri M, Tigaud I, Michallet M, Dumontet C, Thomas X (February 2008). "Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience". Cancer. 112 (3): 572–80. doi:10.1002/cncr.23219. PMID 18085638. S2CID 42107018.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.