UDP-galactose translocator

SLC35A2
Identifiers
Aliases	SLC35A2, CDG2M, CDGX, UDP-Gal-Tr, UGALT, UGAT, UGT, UGT1, UGT2, UGTL, solute carrier family 35 member A2
External IDs	OMIM: 314375 MGI: 1345297 HomoloGene: 136614 GeneCards: SLC35A2
Gene location (Human) Chr. X chromosome (human) Band Xp11.23 Start 48,903,180 bp End 48,911,958 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.1|X 3.56 cM Start 7,750,267 bp End 7,760,731 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte bronchial epithelial cell palpebral conjunctiva stromal cell of endometrium rectum right uterine tube tibia islet of Langerhans body of pancreas left adrenal gland Top expressed in left colon Paneth cell cumulus cell ascending aorta aortic valve crypt of lieberkuhn of small intestine motor neuron seminal vesicula lacrimal gland epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding UDP-galactose transmembrane transporter activity pyrimidine nucleotide-sugar transmembrane transporter activity Cellular component integral component of membrane Golgi membrane Golgi apparatus endoplasmic reticulum nucleus membrane integral component of Golgi membrane Biological process galactose metabolic process carbohydrate transport UDP-galactose transmembrane transport pyrimidine nucleotide-sugar transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7355 22232 Ensembl ENSG00000102100 ENSMUSG00000031156 UniProt P78381 Q9R0M8 RefSeq (mRNA) NM_005660 NM_001032289 NM_001042498 NM_001282647 NM_001282648 NM_001282649 NM_001282650 NM_001282651 NM_001083937 NM_078484 RefSeq (protein) NP_001027460 NP_001035963 NP_001269576 NP_001269577 NP_001269578 NP_001269579 NP_001269580 NP_005651 NP_001077406 NP_511039 Location (UCSC) Chr X: 48.9 – 48.91 Mb Chr X: 7.75 – 7.76 Mb PubMed search
Wikidata
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UDP-galactose translocator is a protein that in humans is encoded by the SLC35A2 gene.

Variants of the SLC35A2 gene haven linked to mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE), which is a subtype of frontal lobe epilepsy.

See also

• Solute carrier family

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Miura N, Ishida N, Hoshino M, Yamauchi M, Hara T, Ayusawa D, Kawakita M (August 1996). "Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator". Journal of Biochemistry. 120 (2): 236–41. doi:10.1093/oxfordjournals.jbchem.a021404. PMID 8889805.
• Ishida N, Miura N, Yoshioka S, Kawakita M (December 1996). "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family". Journal of Biochemistry. 120 (6): 1074–8. doi:10.1093/oxfordjournals.jbchem.a021523. PMID 9010752.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yoshioka S, Sun-Wada GH, Ishida N, Kawakita M (October 1997). "Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter". Journal of Biochemistry. 122 (4): 691–5. doi:10.1093/oxfordjournals.jbchem.a021810. PMID 9399569.
• Aoki K, Ishida N, Kawakita M (June 2001). "Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid". The Journal of Biological Chemistry. 276 (24): 21555–61. doi:10.1074/jbc.M101462200. PMID 11279205.
• Kumamoto K, Goto Y, Sekikawa K, Takenoshita S, Ishida N, Kawakita M, Kannagi R (June 2001). "Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants". Cancer Research. 61 (11): 4620–7. PMID 11389099.
• Sprong H, Degroote S, Nilsson T, Kawakita M, Ishida N, van der Sluijs P, van Meer G (August 2003). "Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum". Molecular Biology of the Cell. 14 (8): 3482–93. doi:10.1091/mbc.E03-03-0130. PMC 181583. PMID 12925779.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.