Andrew G. L. Whitelaw
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Andrew G. L. Whitelaw (born 31 August 1946) is a British neonatologist and academic, known for his work on treating conditions affecting newborn babies. He holds the position of Emeritus Professor at Bristol Medical School, associated with Bristol Neuroscience.[1]
Whitelaw is a member of the Royal College of Physicians and a Fellow of the Royal College of Paediatrics and Child Health. He also served as the president of the Neonatal Society.[2]
Whitelaw research has over 15,553 citations across 9,919 documents. Additionally, his h-index stands at 61.
Early life[edit]
Whitelaw was born in West Fife, Scotland to Robert and Cicely Whitelaw.[3]
Whitelaw received early education at Commercial Primary School.[3]
Research[edit]
Intraventricular Haemorrhage (IVH) and Hydrocephalus in Premature Babies[edit]
One of Whitelaw's notable findings is the efficacy of ventricular lavage in reducing brain injury and disability in post-haemorrhagic hydrocephalus. Ventricular lavage removes toxic substances, such as free iron and pro-inflammatory cytokines, released by old blood.[4][5][6]
Hypoxic-Ischaemic Injury in Full-Term Babies[edit]
Whitelaw's research has involved prevention and treatment of hypoxic-ischaemic injury in full-term newborns. He has been one of the pioneers developing and testing cooling by only a few degrees as a therapeutic approach for neonatal hypoxic-ischaemic encephalopathy. This intervention (therapeutic hypothermia) has been shown to improve the odds of survival without neurological impairment at 18 months of age.[7][8][9]
Awards[edit]
- Raymond Horton-Smith Prize for the best medical thesis of the year (1978).
- President of the Neonatal Society (2006)
- Elected member of the Norwegian Academy of Science and Letters (2016)
Selected publications[edit]
- Whitelaw, Andrew; Jary, Sally; Kmita, Grazyna; Wroblewska, Jolanta; Musialik-Swietlinska, Ewa; Mandera, Marek; Hunt, Linda; Carter, Michael; Pople, Ian (1 April 2010). "Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Posthemorrhagic Ventricular Dilatation: Developmental Outcome at 2 years". Pediatrics. 125 (4): e852–e858. doi:10.1542/peds.2009-1960.
- Gluckman, Peter D; Wyatt, John S; Azzopardi, Denis; Ballard, Roberta; Edwards, A David; Ferriero, Donna M; Polin, Richard A; Robertson, Charlene M; Thoresen, Marianne; Whitelaw, Andrew; Gunn, Alistair J (February 2005). "Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial". The Lancet. 365 (9460): 663–670. doi:10.1016/S0140-6736(05)17946-X.
- Azzopardi, Denis V.; Strohm, Brenda; Edwards, A. David; Dyet, Leigh; Halliday, Henry L.; Juszczak, Edmund; Kapellou, Olga; Levene, Malcolm; Marlow, Neil; Porter, Emma; Thoresen, Marianne; Whitelaw, Andrew; Brocklehurst, Peter (October 2009). "Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy". New England Journal of Medicine. 361 (14): 1349–1358. doi:10.1056/NEJMoa0900854.
- Azzopardi, Denis; Strohm, Brenda; Marlow, Neil; Brocklehurst, Peter; Deierl, Aniko; Eddama, Oya; Goodwin, Julia; Halliday, Henry L.; Juszczak, Edmund; Kapellou, Olga; Levene, Malcolm; Linsell, Louise; Omar, Omar; Thoresen, Marianne; Tusor, Nora; Whitelaw, Andrew; Edwards, A. David (10 July 2014). "Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes". New England Journal of Medicine. 371 (2): 140–149. doi:10.1056/NEJMoa1315788.
- Edwards, A D.; Brocklehurst, P.; Gunn, A. J; Halliday, H.; Juszczak, E.; Levene, M.; Strohm, B.; Thoresen, M.; Whitelaw, A.; Azzopardi, D. (9 February 2010). "Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data". BMJ. 340 (feb09 3): c363–c363. doi:10.1136/bmj.c363. PMC 2819259.
- Draycott, Timothy J.; Crofts, Joanna F.; Ash, Jonathan P.; Wilson, Louise V.; Yard, Elaine; Sibanda, Thabani; Whitelaw, Andrew (July 2008). "Improving Neonatal Outcome Through Practical Shoulder Dystocia Training". Obstetrics & Gynecology. 112 (1): 14–20. doi:10.1097/AOG.0b013e31817bbc61.
- Draycott, Tim; Sibanda, Thabani; Owen, Louise; Akande, Valentine; Winter, Cathy; Reading, Sandra; Whitelaw, Andrew (February 2006). "Does training in obstetric emergencies improve neonatal outcome?". BJOG: An International Journal of Obstetrics & Gynaecology. 113 (2): 177–182. doi:10.1111/j.1471-0528.2006.00800.x.
- Miall-Allen, V M; de Vries, L S; Whitelaw, A G (1 October 1987). "Mean arterial blood pressure and neonatal cerebral lesions". Archives of Disease in Childhood. 62 (10): 1068–1069. doi:10.1136/adc.62.10.1068. PMC 1778679.
References[edit]
- ^ "Professor Andrew Whitelaw". University of Bristol.
- ^ "expert reaction to study looking at paracetamol in pregnancy and behaviour, memory and IQ in children | Science Media Centre". Science Media Centre.
- ^ a b "New book lifts lid on Dunfermline childhood in 1950s". Dunfermline Press. 14 May 2023.
- ^ "Surgical technique for premature babies with brain haemorrhage reduces long-term disability". News-Medical. 6 July 2020.
- ^ "July: DRIFT10-study". University of Bristol.
- ^ "Intraventricular haemorrhage and posthaemorrhagic hydrocephalus: pathogenesis, prevention and future interventions". Seminars in Fetal and Neonatal Medicine.
- ^ "Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial". Lancet Neurology. 1 January 2010. pp. 39–45. doi:10.1016/S1474-4422(09)70295-9.
- ^ "2010: Clinical Science at North Bristol | News and features | University of Bristol". University of Bristol.
- ^ "Time Course of Brainstem Pathophysiology during First Month in Term Infants after Perinatal Asphyxia, Revealed by MLS BAER Latencies and Intervals". Pediatric Research. November 2003. pp. 680–687. doi:10.1203/01.PDR.0000084084.62571.12.