SPOCK1

SPOCK1
Identifiers
Aliases	SPOCK1, SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
External IDs	OMIM: 602264 MGI: 105371 HomoloGene: 80193 GeneCards: SPOCK1
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.2 Start 136,975,298 bp End 137,598,379 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 B1 Start 57,569,008 bp End 58,056,146 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium postcentral gyrus Brodmann area 46 orbitofrontal cortex cerebellar cortex cerebellar hemisphere superior frontal gyrus entorhinal cortex inferior olivary nucleus pons Top expressed in medial dorsal nucleus medial geniculate nucleus superior frontal gyrus olfactory epithelium cerebellar cortex anterior horn of spinal cord lateral geniculate nucleus primary motor cortex prefrontal cortex dorsomedial hypothalamic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding cysteine-type endopeptidase inhibitor activity metalloendopeptidase inhibitor activity serine-type endopeptidase inhibitor activity collagen binding extracellular matrix binding Cellular component cytoplasm postsynaptic density neuromuscular junction node of Ranvier extracellular region sarcoplasm extracellular space Biological process negative regulation of cell-substrate adhesion neurogenesis negative regulation of neuron projection development neuron migration nervous system development cell adhesion regulation of cell growth central nervous system neuron differentiation signal transduction negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6695 20745 Ensembl ENSG00000152377 ENSMUSG00000056222 UniProt Q08629 Q62288 RefSeq (mRNA) NM_004598 NM_001166463 NM_001166464 NM_001166465 NM_001166466 NM_009262 RefSeq (protein) NP_004589 n/a Location (UCSC) Chr 5: 136.98 – 137.6 Mb Chr 13: 57.57 – 58.06 Mb PubMed search
Wikidata
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Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.

Further reading

• Périn JP, Alliel PM, Jollès P, Bonnet F (1994). "Proteoglycans in male reproductive tract". Exs. 70: 191–7. doi:10.1007/978-3-0348-7545-5_11 (inactive 2024-02-07). ISBN 978-3-0348-7547-9. PMID 7507743.{{cite journal}}: CS1 maint: DOI inactive as of February 2024 (link)
• Charbonnier F, Périn JP, Roussel G, et al. (1997). "[Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology]". C. R. Séances Soc. Biol. Fil. 191 (1): 127–33. PMID 9181134.
• Alliel PM, Perin JP, Jollès P, Bonnet FJ (1993). "Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour". Eur. J. Biochem. 214 (1): 347–50. doi:10.1111/j.1432-1033.1993.tb17930.x. PMID 8389704.
• Bonnet F, Périn JP, Charbonnier F, et al. (1996). "Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells". J. Biol. Chem. 271 (8): 4373–80. doi:10.1074/jbc.271.8.4373. PMID 8626787.
• Marr HS, Basalamah MA, Edgell CJ (1998). "Endothelial cell expression of testican mRNA". Endothelium. 5 (3): 209–19. doi:10.3109/10623329709053399. PMID 9272383.
• Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). "Properties of the extracellular calcium binding module of the proteoglycan testican". FEBS Lett. 414 (3): 557–61. doi:10.1016/S0014-5793(97)01070-3. PMID 9323035. S2CID 25552375.
• Marr HS, Basalamah MA, Bouldin TW, et al. (2001). "Distribution of testican expression in human brain". Cell Tissue Res. 302 (2): 139–44. doi:10.1007/s004410000277. PMID 11131125. S2CID 9937680.
• BaSalamah MA, Marr HS, Duncan AW, Edgell CJ (2001). "Testican in human blood". Biochem. Biophys. Res. Commun. 283 (5): 1083–90. doi:10.1006/bbrc.2001.4900. PMID 11355883.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Res. 63 (12): 3364–9. PMID 12810672.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022.
• Prenzel KL, Warnecke-Eberz U, Xi H, et al. (2006). "Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater". Oncol. Rep. 15 (5): 1397–401. doi:10.3892/or.15.5.1397. PMID 16596217.