Whirly
| Whirly | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Whirly | ||||||||
| Pfam | PF08536 | ||||||||
| InterPro | IPR013742 | ||||||||
| |||||||||
In molecular biology, the protein domain Whirly is a transcription factor commonly found in plants. This means they aid the transcription of genes from DNA into a complementary copy of mRNA. In particular, in plants, they aid the transcription of plant defence genes.[1]
Function[edit]
The function of Whirly proteins is to regulate the expression of genes that aid defence. They are transcription factors which bind to single stranded DNA in order to regulate gene expression. When a pathogen enters, salicylic acid is released as a signalling molecule which affects Whirly, allowing the expression of defence genes to occur.[1]
Structure[edit]
This protein contains 10 beta strands and 2 alpha helices.[2]
History[edit]
PBF-2 was the first protein in the Whirly family to be discovered.[1] In the past, the protein has also been named p24.[3]
References[edit]
- ^ a b c Desveaux D, Maréchal A, Brisson N (February 2005). "Whirly transcription factors: defense gene regulation and beyond". Trends Plant Sci. 10 (2): 95–102. doi:10.1016/j.tplants.2004.12.008. PMID 15708347.
- ^ Cappadocia L, Maréchal A, Parent JS, Lepage E, Sygusch J, Brisson N (June 2010). "Crystal structures of DNA-Whirly complexes and their role in Arabidopsis organelle genome repair". Plant Cell. 22 (6): 1849–67. doi:10.1105/tpc.109.071399. PMC 2910959. PMID 20551348.
- ^ Desveaux D, Allard J, Brisson N, Sygusch J (July 2002). "A new family of plant transcription factors displays a novel ssDNA-binding surface". Nat. Struct. Biol. 9 (7): 512–7. doi:10.1038/nsb814. PMID 12080340. S2CID 1197793.