CHST10

CHST10
Identifiers
Aliases	CHST10, HNK-1ST, HNK1ST, carbohydrate sulfotransferase 10
External IDs	OMIM: 606376 MGI: 2138283 HomoloGene: 21013 GeneCards: CHST10
Gene location (Human)
Chr.	Chromosome 2 (human)
End	100,417,668 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	38,937,242 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; middle temporal gyrus; ; frontal pole; ; Brodmann area 10; ; Brodmann area 9; ; secondary oocyte; ; putamen; ; nucleus accumbens; ; cingulate gyrus; ; caudate nucleus;
	Top expressed in
	visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; medial dorsal nucleus; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; habenula; ; dorsomedial hypothalamic nucleus; ; superior colliculus; ; medial geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; HNK-1 sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	cell adhesion; carbohydrate biosynthetic process; carbohydrate metabolic process; proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9486
	98388
	ENSG00000115526
	ENSMUSG00000026080
	O43529
	Q6PGK7
	NM_004854
	NM_145142; NM_001368780
	NP_004845
	NP_660124; NP_001355709
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.^[5]^[6]

Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026080 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.
^ ^a ^b "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

External links[edit]

Human CHST10 genome location and CHST10 gene details page in the UCSC Genome Browser.

Further reading[edit]

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ong E, Yeh JC, Ding Y, et al. (1999). "Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis". J. Biol. Chem. 274 (36): 25608–12. doi:10.1074/jbc.274.36.25608. PMID 10464296.
Ong E, Yeh JC, Ding Y, et al. (1998). "Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids". J. Biol. Chem. 273 (9): 5190–5. doi:10.1074/jbc.273.9.5190. PMID 9478973.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026080 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12080076-5] Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.

[entrez-6] "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

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