hya RNA motif
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|
| hya | |
|---|---|
 Consensus secondary structure and sequence conservation of hya RNA | |
| Identifiers | |
| Symbol | hya |
| Rfam | RF02992 |
| Other data | |
| RNA type | Cis-reg |
| SO | SO:0005836 |
| PDB structures | PDBe |
The hya RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] hya motif RNAs are found in Actinomycetota.
hya motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. Indeed, the RNAs are upstream of multiple genes that encode non-homologous proteins. If all examples of the RNA were upstream of homologous genes, there is the possibility that the RNAs were conserved in that position simply by inheritance. The non-homology of the genes downstream of hya RNAs makes this scenario less likely. The genes presumably regulated by hya RNAs are subunits of nickel-iron hydrogenase I.
References[edit]
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.