Endogenous retrovirus group V member 2, envelope

ERVV-2
Identifiers
Aliases	ERVV-2, ENVV2, HERV-V2, endogenous retrovirus group V member 2, endogenous retrovirus group V member 2, envelope
External IDs	HomoloGene: 130358 GeneCards: ERVV-2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.41 Start 53,044,740 bp End 53,051,680 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta renal cortex kidney left lobe of thyroid gland n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100271846 n/a Ensembl ENSG00000268964 n/a UniProt B6SEH9 n/a RefSeq (mRNA) NM_001191055 n/a RefSeq (protein) NP_001177984 n/a Location (UCSC) Chr 19: 53.04 – 53.05 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Endogenous retrovirus group V member 2, envelope is a protein that in humans is encoded by the ERVV-2 gene.

Function

Many human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.