Myogel
Myogel is a trade name for a human-based extracellular matrix used in cancer research to provide a 3D cell culture environment for cancer cells. Unlike other synthesized matrices such as matrigel which originated from mice sarcoma, myogel is extracted from a human benign tumor tissue called leiomyoma. Myogel was developed in Tuula Salo's lab at the University of Oulu. The idea started in 2009 by culturing cancer cells on myoma discs.[1] Later in 2015, these myoma tissues were processed following matrigel receipt, to extract a gel form called Myogel.[2] Myogel was compared with matrigel and found to be superior in term of enhancing cancer cells proliferation, migration and invasion.[2]
References[edit]
- ^ Nurmenniemi, Sini; Sinikumpu, Teemu; Alahuhta, Ilkka; Salo, Sirpa; Sutinen, Meeri; Santala, Markku; Risteli, Juha; Nyberg, Pia; Salo, Tuula (September 2009). "A Novel Organotypic Model Mimics the Tumor Microenvironment". The American Journal of Pathology. 175 (3): 1281–1291. doi:10.2353/ajpath.2009.081110. PMC 2731146. PMID 19679876.
- ^ a b Salo, Tuula; Sutinen, Meeri; Hoque Apu, Ehsanul; Sundquist, Elias; Cervigne, Nilva K.; de Oliveira, Carine Ervolino; Akram, Saad Ullah; Ohlmeier, Steffen; Suomi, Fumi; Eklund, Lauri; Juusela, Pirjo (December 2015). "A novel human leiomyoma tissue derived matrix for cell culture studies". BMC Cancer. 15 (1): 981. doi:10.1186/s12885-015-1944-z. ISSN 1471-2407. PMC 4682271. PMID 26673244. S2CID 17598911.
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