Maria-Elena Torres-Padilla

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Maria-Elena Torres-Padilla
NationalityMexican
Alma mater
Known fortotipotency, pluripotency, early embryo, epigenetics, chromatin architecture
Scientific career
Fields
Institutions
WebsiteTorres-Padilla Lab

Maria-Elena Torres-Padilla is a Mexican biologist who is the Director of the Stem Cell Center,[1] the Director of the Institute for Epigenetics and Stem Cells (IES),[2] and a Group Leader at the Helmholtz Zentrum München, Germany.[3]

Education[edit]

From 1994 until 1998, Torres-Padilla completed her undergraduate studies at the Faculty of Sciences of the National Autonomous University of Mexico in Mexico and earned her Ph.D. from the Institut Pasteur in Paris in 2002.[4][5]

Career and research[edit]

Between 2002 and 2006, she was a postdoctoral fellow at The Gurdon Institute, University of Cambridge, UK, after which she worked as a permanent scientist under Laszlo Tora's supervision.[6][7]

Since December 2008, she has led her research group at the Institute of Genetics, Molecular and Cellular Biology (IGBMC) in Strasbourg, France.[8][9][10] In January 2016, the lab was relocated to the Institute of Epigenetics and Stem Cells at the Helmholtz Zentrum München, Germany.[11][12]

The primary objective of Torres-Padilla's research activities is to comprehend the manner in which epigenetic information controls the shifts in cellular identity and cellular reprogramming. This is crucial in comprehending pluripotent stem cell biology, particularly their development and origin. The work also endeavors to gain insight into the early stages of embryonic development, human reproduction, fertility, and stem cell biology from a broader perspective.[13][14][15]

Torres-Padilla is an editorial board member of Science,[16] Development,[17] Genes & Development,[18] and Scientific Reports.[19]

Awards and honours[edit]

References[edit]

  1. ^ "Helmholtz Munich".
  2. ^ "Helmholtz Munich". 20 December 2023.
  3. ^ "Helmholtz Munich".
  4. ^ "Torres-Padilla, Maria Elena - SFB 1064 - LMU Munich".
  5. ^ "Academy of Europe: Torres-Padilla Maria-Elena".
  6. ^ Torres-Padilla, Maria-Elena; Parfitt, David-Emlyn; Kouzarides, Tony; Zernicka-Goetz, Magdalena (2007). "Histone arginine methylation regulates pluripotency in the early mouse embryo". Nature. 445 (7124): 214–218. Bibcode:2007Natur.445..214T. doi:10.1038/nature05458. PMC 3353120. PMID 17215844.
  7. ^ Torres-Padilla, Maria-Elena; Bannister, Andrew J.; Hurd, Paul J.; Kouzarides, Tony; Zernicka-Goetz, Magdalena (2006). "Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos". The International Journal of Developmental Biology. 50 (5): 455–461. doi:10.1387/ijdb.052073mt. PMID 16586346.
  8. ^ Miyanari, Yusuke; Torres-Padilla, Maria-Elena (2012). "Control of ground-state pluripotency by allelic regulation of Nanog". Nature. 483 (7390): 470–473. Bibcode:2012Natur.483..470M. doi:10.1038/nature10807. PMID 22327294.
  9. ^ Santenard, Angèle; Ziegler-Birling, Céline; Koch, Marc; Tora, Làszlò; Bannister, Andrew J.; Torres-Padilla, Maria-Elena (2010). "Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3". Nature Cell Biology. 12 (9): 853–862. doi:10.1038/ncb2089. PMC 3701880. PMID 20676102.
  10. ^ Ishiuchi, Takashi; Enriquez-Gasca, Rocio; Mizutani, Eiji; Bošković, Ana; Ziegler-Birling, Celine; Rodriguez-Terrones, Diego; Wakayama, Teruhiko; Vaquerizas, Juan M.; Torres-Padilla, Maria-Elena (2015). "Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly". Nature Structural & Molecular Biology. 22 (9): 662–671. doi:10.1038/nsmb.3066. PMID 26237512.
  11. ^ Jachowicz, Joanna W.; Bing, Xinyang; Pontabry, Julien; Bošković, Ana; Rando, Oliver J.; Torres-Padilla, Maria-Elena (2017). "LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo". Nature Genetics. 49 (10): 1502–1510. doi:10.1038/ng.3945. PMID 28846101.
  12. ^ Nakatani, Tsunetoshi; Lin, Jiangwei; Ji, Fei; Ettinger, Andreas; Pontabry, Julien; Tokoro, Mikiko; Altamirano-Pacheco, Luis; Fiorentino, Jonathan; Mahammadov, Elmir; Hatano, Yu; Van Rechem, Capucine; Chakraborty, Damayanti; Ruiz-Morales, Elias R.; Arguello Pascualli, Paola Y.; Scialdone, Antonio; Yamagata, Kazuo; Whetstine, Johnathan R.; Sadreyev, Ruslan I.; Torres-Padilla, Maria-Elena (2022). "DNA replication fork speed underlies cell fate changes and promotes reprogramming". Nature Genetics. 54 (3): 318–327. doi:10.1038/s41588-022-01023-0. PMC 8920892. PMID 35256805.
  13. ^ Rodriguez-Terrones, Diego; Gaume, Xavier; Ishiuchi, Takashi; Weiss, Amélie; Kopp, Arnaud; Kruse, Kai; Penning, Audrey; Vaquerizas, Juan M.; Brino, Laurent; Torres-Padilla, Maria-Elena (2018). "A molecular roadmap for the emergence of early-embryonic-like cells in culture". Nature Genetics. 50 (1): 106–119. doi:10.1038/s41588-017-0016-5. PMC 5755687. PMID 29255263.
  14. ^ Bell, Oliver; Burton, Adam; Dean, Caroline; Gasser, Susan M.; Torres-Padilla, Maria-Elena (2023). "Heterochromatin definition and function". Nature Reviews Molecular Cell Biology. 24 (10): 691–694. doi:10.1038/s41580-023-00599-7. PMID 37069331.
  15. ^ Chimal-Monroy, Jesús; Escalante-Alcalde, Diana (2021). "Epigenetic control of cell fate - an interview with Maria-Elena Torres-Padilla". The International Journal of Developmental Biology. 65 (1–2–3): 163–169. doi:10.1387/ijdb.200176jc. PMID 32930362.
  16. ^ https://www.science.org/content/page/editors-and-advisory-boards
  17. ^ https://journals.biologists.com/dev/pages/edboard
  18. ^ "Genes & Development -- Genes & Development Editorial Board".
  19. ^ "Editors | Scientific Reports".
  20. ^ https://erc.europa.eu/sites/default/files/document/file/erc_2011_stg_results_all_domains.pdf
  21. ^ "Nuclear foundations of cellular potency | NUCLEARPOTENCY Project | Fact Sheet | FP7".
  22. ^ "Find people in the EMBO Communities".
  23. ^ "German Stem Cell Network Awards".
  24. ^ https://journals.biologists.com/dev/article/146/23/dev186288/224281/An-interview-with-Maria-Elena-Torres-Padilla
  25. ^ "ACAL, Académicos 2022-2023 | ACAL".
  26. ^ "Helmholtz Munich". 25 May 2023.
  27. ^ "List of Members".
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