folE RNA motif
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|
| folE | |
|---|---|
 Consensus secondary structure and sequence conservation of folE RNA | |
| Identifiers | |
| Symbol | folE |
| Rfam | RF02977 |
| Other data | |
| RNA type | Cis-reg |
| SO | SO:0005836 |
| PDB structures | PDBe |
The folE RNA motif, now known as the THF-II riboswitch, is a conserved RNA structure that was discovered by bioinformatics.[1] folE motifs are found in Alphaproteobacteria.
folE motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. Instances of the folE RNA motif are often located nearby to the predicted Shine-Dalgarno sequence of the downstream gene. This arrangement is consistent with a model of cis-regulation where the RNA allosterically controls access to the Shine-Dalgarno sequence, thus regulating the gene translationally. All known folE RNAs are present upstream of genes encoding GTP cyclohydrolase I, which performs a step in folate metabolism.
folE RNAs have been shown to bind tetrahydrofolate and related molecules, leading to their designation as a second structural class of tetrahydrofolate riboswitches, called THF-II riboswitches.[2]
References[edit]
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.
- ^ Chen X, Mirihana Arachchilage G, Breaker RR (September 2019). "Biochemical validation of a second class of tetrahydrofolate riboswitches in bacteria". RNA. 25 (9): 1091–1097. doi:10.1261/rna.071829.119. PMC 6800512. PMID 31186369.