LGALS13

LGALS13
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1F87
Identifiers
Aliases	LGALS13, GAL13, PLAC8, PP13, galectin 13
External IDs	OMIM: 608717 HomoloGene: 49329 GeneCards: LGALS13
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,607,474 bp
RNA expression pattern
	Top expressed in
	placenta; ; thymus; ; striated muscle tissue; ; skeletal muscle tissue; ; thigh; ; cerebellum; ; cerebellar cortex; ; hypothalamus; ; substantia nigra; ; cell;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lysophospholipase activity; protein binding; carbohydrate binding;
Cellular component	cytoplasm; nuclear matrix; nucleus;
Biological process	phospholipid metabolic process; positive regulation of T cell apoptotic process; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	29124
	n/a
	ENSG00000105198
	n/a
	Q9UHV8
	n/a
	NM_013268
	n/a
	NP_037400
	n/a
	Wikidata
View/Edit Human

Placental protein 13 (PP13) is a protein that in humans is encoded by the LGALS13 gene.^[3]^[4]

Structure and function[edit]

Function[edit]

It is composed of two identical subunits which are held together by disulfide bonds. The monomer of this protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family, but it could not bind beta-galactoside. This is because the ligand binding site is lack of key residue for binding beta-galactoside. ^[5]It is a galectin-like protein. The ligand of this protein is still unknown.

Clinical significance[edit]

PP13 levels that are low in the first trimester of pregnancy confers a higher risk for developing pre-eclampsia later in pregnancy.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105198 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bohn H, Kraus W, Winckler W (Jul 1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)". Oncodevelopmental Biology and Medicine. 4 (5): 343–50. PMID 6856484.
^ Than NG, Sumegi B, Than GN, Berente Z, Bohn H (November 1999). "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein". Placenta. 20 (8): 703–10. doi:10.1053/plac.1999.0436. PMID 10527825.
^ Su J, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y (January 2018). "Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138". Scientific Reports. 8 (1): 980. Bibcode:2018NatSR...8..980S. doi:10.1038/s41598-018-19465-0. PMC 5772480. PMID 29343868.
^ Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M (February 2013). "Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia". Human Reproduction Update. 19 (4): 391–405. doi:10.1093/humupd/dmt003. PMID 23420029.

External links[edit]

Overview of all the structural information available in the PDB for UniProt: Q9UHV8 (Human Galactoside-binding soluble lectin 13) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105198 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6856484-3] Bohn H, Kraus W, Winckler W (Jul 1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)". Oncodevelopmental Biology and Medicine. 4 (5): 343–50. PMID 6856484.

[pmid10527825-4] Than NG, Sumegi B, Than GN, Berente Z, Bohn H (November 1999). "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein". Placenta. 20 (8): 703–10. doi:10.1053/plac.1999.0436. PMID 10527825.

[pmid29343868-5] Su J, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y (January 2018). "Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138". Scientific Reports. 8 (1): 980. Bibcode:2018NatSR...8..980S. doi:10.1038/s41598-018-19465-0. PMC 5772480. PMID 29343868.

[pmid23420029-6] Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M (February 2013). "Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia". Human Reproduction Update. 19 (4): 391–405. doi:10.1093/humupd/dmt003. PMID 23420029.

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