Colforsin daropate
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| ECHA InfoCard | 100.215.763 |
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| Formula | C27H43NO8 |
| Molar mass | 509.640 g·mol−1 |
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Colforsin daropate is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine.[1]
Its water-soluble hydrochloride salt (NKH 477)[2] is an adenylyl cyclase activator which has been studied for its cardiac selectivity.[3][4]
Its parent compound forskolin (colforsin) is also used to raise levels of cAMP in the study of cell physiology.[5]
References[edit]
- ^ "colforsin daropate". ChEBI. EMBL-EBI. Retrieved 6 January 2022.
- ^ "β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride (1:1)". CAS Common Chemistry. American Chemical Society. Retrieved 6 January 2022.
- ^ Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yokoyama M (August 1994). "Effect of NKH477, a new water-soluble forskolin derivative, on arterial-ventricular coupling and mechanical energy transduction in patients with left ventricular systolic dysfunction: comparison with dobutamine". J. Cardiovasc. Pharmacol. 24 (2): 310–6. doi:10.1097/00005344-199424020-00018. PMID 7526066.
- ^ Sanbe A, Takeo S (July 1995). "Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction". J. Pharmacol. Exp. Ther. 274 (1): 120–6. PMID 7616388.
- ^ "Colforsin (Forskolin, HL 362) | ≥99%(HPLC) | Selleck | cAMP activator". selleckchem.com. Retrieved 2021-10-25.
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