DDX42

DDX42
Identifiers
Aliases	DDX42, DDX42P, RHELP, RNAHP, SF3B8, SF3b125, DEAD-box helicase 42
External IDs	OMIM: 613369 MGI: 1919297 HomoloGene: 49137 GeneCards: DDX42
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,819,317 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,249,139 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right uterine tube; ; gastric mucosa; ; Achilles tendon; ; canal of the cervix; ; sural nerve; ; minor salivary glands; ; gallbladder; ; rectum; ; left uterine tube;
	Top expressed in
	neural tube; ; lens; ; superior frontal gyrus; ; yolk sac; ; thymus; ; primitive streak; ; ganglionic eminence; ; cumulus cell; ; cerebellar cortex; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; hydrolase activity; ATP binding; helicase activity; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; Cajal body; membrane; nucleus; nucleoplasm; cytosol; nuclear speck; nucleolus;
Biological process	protein localization; RNA secondary structure unwinding; mRNA splicing, via spliceosome; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	11325
	72047
	ENSG00000198231
	ENSMUSG00000020705
	Q86XP3
	Q810A7
	NM_007372; NM_203499
	NM_028074
	NP_031398; NP_987095
	NP_082350; NP_001348569; NP_001348571; NP_001348572; NP_001348573
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.^[5]^[6]

Function[edit]

This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.^[6]

Interactions[edit]

DDX42 has been shown to interact with SF3B1.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198231 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS (Apr 2000). "Identification of a novel human member of the DEAD box protein family". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1501 (1): 63–9. doi:10.1016/S0925-4439(00)00010-7. PMID 10727850.
^ ^a ^b "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42".
^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

Further reading[edit]

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Uhlmann-Schiffler H, Jalal C, Stahl H (2006). "Ddx42p--a human DEAD box protein with RNA chaperone activities". Nucleic Acids Research. 34 (1): 10–22. doi:10.1093/nar/gkj403. PMC 1325199. PMID 16397294.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198231 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020705 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10727850-5] Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS (Apr 2000). "Identification of a novel human member of the DEAD box protein family". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1501 (1): 63–9. doi:10.1016/S0925-4439(00)00010-7. PMID 10727850.

[entrez-6] "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42".

[pmid12234937-7] Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

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