LZTS1

LZTS1
Identifiers
Aliases	LZTS1, F37, FEZ1, leucine zipper, putative tumor suppressor 1, leucine zipper tumor suppressor 1
External IDs	OMIM: 606551 MGI: 2684762 HomoloGene: 10873 GeneCards: LZTS1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	20,303,963 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	69,636,877 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; nucleus accumbens; ; Brodmann area 23; ; caudate nucleus; ; amygdala; ; prefrontal cortex; ; putamen; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; endothelial cell;
	Top expressed in
	olfactory tubercle; ; piriform cortex; ; Region I of hippocampus proper; ; superior frontal gyrus; ; nucleus accumbens; ; primary motor cortex; ; amygdala; ; ganglionic eminence; ; secondary oocyte; ; prefrontal cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; protein binding; microtubule binding;
Cellular component	cytoplasm; postsynaptic membrane; cell projection; membrane; postsynaptic density; plasma membrane; dendritic spine; synapse; cell junction; apical plasma membrane; neuron projection; dendritic shaft; cell body;
Biological process	negative regulation of macroautophagy; transcription, DNA-templated; cell cycle; regulation of transcription, DNA-templated; mitotic cell cycle phase transition; regulation of synaptic plasticity; regulation of dendrite morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	11178
	211134
	ENSG00000061337
	ENSMUSG00000036306
	Q9Y250
	P60853
	NM_021020; NM_001362884
	NM_199364; NM_001370971
	NP_066300; NP_001349813
	NP_955396; NP_001357900
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.^[5]^[6]^[7]

In melanocytic cells LZTS1 gene expression may be regulated by MITF.^[8]

Interactions[edit]

LZTS1 has been shown to interact with EEF1G.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000061337 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. Bibcode:1999PNAS...96.3928I. doi:10.1073/pnas.96.7.3928. PMC 22397. PMID 10097140.
^ Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM (Mar 2007). "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC 1987708. PMID 17349584.
^ "Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1".
^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
^ Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (Aug 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. Bibcode:2001PNAS...9810374I. doi:10.1073/pnas.181222898. PMC 56968. PMID 11504921.

Further reading[edit]

Ono K, Uzawa K, Nakatsuru M, Shiiba M, Mochida Y, Tada A, Bukawa H, Miyakawa A, Yokoe H, Tanzawa H (2004). "Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas". Int. J. Oncol. 23 (2): 297–302. doi:10.3892/ijo.23.2.297. PMID 12851677.
Hawkins GA, Mychaleckyj JC, Zheng SL, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang BL, Ewing CM, Bujnovszky P, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J (2002). "Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk". Cancer Genet. Cytogenet. 137 (1): 1–7. doi:10.1016/S0165-4608(02)00549-6. PMID 12377406.
Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. Bibcode:2001PNAS...9810374I. doi:10.1073/pnas.181222898. PMC 56968. PMID 11504921.
Cabeza-Arvelaiz Y, Sepulveda JL, Lebovitz RM, Thompson TC, Chinault AC (2001). "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22". Oncogene. 20 (31): 4169–79. doi:10.1038/sj.onc.1204539. PMID 11464283. S2CID 38760860.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000061337 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036306 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10097140-5] Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. Bibcode:1999PNAS...96.3928I. doi:10.1073/pnas.96.7.3928. PMC 22397. PMID 10097140.

[pmid17349584-6] Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM (Mar 2007). "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC 1987708. PMID 17349584.

[entrez-7] "Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1".

[pmid19067971-8] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

[pmid11504921-9] Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (Aug 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. Bibcode:2001PNAS...9810374I. doi:10.1073/pnas.181222898. PMC 56968. PMID 11504921.

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