FAM18B1

TVP23B
Identifiers
Aliases	TVP23B, FAM18B, FAM18B1, NPD008, YDR084C, CGI-148, trans-golgi network vesicle protein 23 homolog B (S. cerevisiae), trans-golgi network vesicle protein 23 homolog B
External IDs	MGI: 1914760 HomoloGene: 128511 GeneCards: TVP23B
Gene location (Human) Chr. Chromosome 17 (human) Band 17p11.2 Start 18,781,111 bp End 18,806,714 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B2 Start 62,770,281 bp End 62,807,606 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Achilles tendon stromal cell of endometrium body of pancreas rectum anterior pituitary gallbladder salivary gland minor salivary glands duodenum Top expressed in otolith organ utricle superior cervical ganglion olfactory epithelium parotid gland seminal vesicula ciliary body submandibular gland atrioventricular valve retinal pigment epithelium More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 51030 67510 Ensembl ENSG00000171928 ENSMUSG00000014177 UniProt Q9NYZ1 Q9D8T4 RefSeq (mRNA) NM_016078 NM_001316919 NM_001316920 NM_001316921 NM_001316922 NM_001316923 NM_001316924 NM_026210 NM_001356520 NM_001356521 RefSeq (protein) NP_001303848 NP_001303849 NP_001303850 NP_001303851 NP_001303852 NP_001303853 NP_057162 NP_080486 NP_001343449 NP_001343450 Location (UCSC) Chr 17: 18.78 – 18.81 Mb Chr 11: 62.77 – 62.81 Mb PubMed search
Wikidata
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Family with sequence similarity 18 member B1 (FAM18B1) is the hypothetical protein encoded by the gene LOC51030. Evidence for this protein only exists at the transcript level. The gene is found on chromosome 17 on the cytogenetic band 17p11.2.

This gene has two paralog in the human genome, LOC201158, which is located on chromosome 17 at 17p12, and TVP23A, which is located on chromosome 16. The duplication appears to have appeared after the MRCA of humans and apes. This gene has homologs in eukaryotes as far back as Trichoplax.

Gene

LOC51030 is highly conserved in chordates and also shows conservation in eukaryotes, including fungi and plants. It is located on Chromosome 17 at 18,684,582-18,710,026, and the most common mRNA has 7 exons.

Protein

This gene encode a protein of 205 amino acids in length and a predicted molecular weight of 23.57 kDa. This protein is predicted to have an isoelectric point of 8.62. It contains a domain of unknown function, DUF846, and a predicted phosphoserine site. It is a multipass transmembrane protein and a member of the FAM18/TVP23 superfamily.

FAM18B1 appears to be ubiquitously expressed in all tissues, health states, and developmental stages to some level. There is also notable expression in bladder tissue.