Chi Hwan Lee

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Chi Hwan Lee
Occupation(s)Biomedical engineer, academic, and researcher
AwardsYoung Investigator Award, Korean-American Scientists and Engineers Association (KSEA)
Trailblazer Award, National Institutes of Health (NIH)
Sensors Young Investigator Award, Sensors
Academic background
Alma materAjou University
Illinois Institute of Technology
Stanford University
Academic work
InstitutionsPurdue University

Chi Hwan Lee is an American biomedical engineer, academic, and researcher. He is the Leslie A. Geddes Associate Professor of Biomedical Engineering and associate professor of mechanical engineering, and by courtesy, of materials engineering and speech, language, and hearing sciences at Purdue University.[1]

Lee has published over 70 journal papers and 4 book chapters,[2] issued 27 patents,[3] and launched 3 startup companies. He has focused his research on wearable healthcare technologies, tele-medicine, functional soft biomaterials, stretchable bioelectronics, drug delivery systems, and smart manufacturing processes.[4]

Early life and education[edit]

Lee graduated with a B.E. degree in industrial engineering from Ajou University in 2006. He then emigrated to United States, earning his dual B.S. degree in mechanical engineering at Illinois Institute of Technology in 2007. He obtained his M.S. and Ph.D. degrees in mechanical engineering from Stanford University in 2009 and 2013, respectively. From 2013 till 2015, he was a postdoctoral research associate in Department of Materials Science and Engineering at University of Illinois at Urbana-Champaign.)[5]

Career[edit]

Following his postdoctoral training, Lee joined Purdue University as an assistant professor in 2015, and became Leslie A. Geddes Assistant Professor in 2020, and Leslie A. Geddes Associate Professor in 2021. Since 2021, he has been serving as Industry Advisory Board (IAB) Professor at Hanyang University.[1]

Lee has been appointed as a scientific advisor for Omniply Technologies since 2018; as chief technical officer (CTO) of Rescue Biomedical, since 2019; and has also served as chief technical officer (CTO) of Curasis from 2018 to 2021. He developed and led an international dual MS degree program in the Weldon School of Biomedical Engineering and the School of Mechanical Engineering at Purdue University with Hanyang University.[6]

Research[edit]

Lee's research is focused on the development of wearable biomedical devices, with particular attention on the scalable production of stretchable sensors in quantities required for clinical testing, and ultimately widespread applications.[7]

Clinical and healthcare practices[edit]

Lee has made significant contribution towards the development of a skin sensor patch tailored for various human body parts in order to detect clinically important biosignals in real time.[8]

Lee is also a pioneer in the development of a soft patch featured with miniaturized functional needles for applications involving intracellular delivery of biomolecules as well as intracellular recording of electrophysiological signals at the cellular scale. He designed these devices to enable placement of the needles at characteristic dimensions equivalent to those of human cells, as well as provide the basis for interactions with the surrounding tissue defined by these cells.[9][10]

Wearable biomedical technology[edit]

Lee along with his team also works to develop wearable technology for animals by enabling direct printing of functional nanomaterials into textile weave of commercial blankets for animals over large scale. Lee has teamed up with Laurent Couetil in Purdue Veterinary Medicine to develop a smart connected blanket for horse with asthma in order to monitor respiration rate continuously, or even overnight, from a distance.[11][12][13]

These devices were made possible by the discovery and development of transfer printing of thin film electronics by Lee and his colleagues. Lee's method prints a nearly infinite number of thin film electronics on a single wafer, which are then delaminated from the wafer using simply water. The thin film electronics are then placed and bonded on elastic surfaces to form flexible devices.[14]

Drug delivery systems[edit]

In 2022, Lee introduced a new concept of drug delivery system using a combination of silicon nanoneedles and a tear-soluble contact lens, enabling the painless and long-term sustained release of ocular drugs into eyes. Lee teamed up with Yanni Paulus in the University of Michigan Medicine to demonstrate the utility of the drug delivery system in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a noticeable side effect over current standard therapies. In his early works, Lee introduced a wirelessly operated, implantable drug delivery system using a combination of thermally actuated lipid membranes embedded with multiple types of drugs. He also discussed underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of the system.[15] In another study, he presented a system in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. He demonstrated the applications of this technology in terms of the treatment of cancerous tissues by release of the drug doxorubicin.[16] Moreover, he presented a review on the emerging trends and latest innovations of wearable glucose monitoring and implantable insulin delivery technologies for diabetes management with a focus on their advanced materials and construction.[17]

Awards and honors[edit]

  • 2013 – Graduate Student Silver Award, Materials Research Society (MRS)
  • 2013 – Top Innovation Award, Technology Connect World National Innovation Summit
  • 2014 – Best Talk Award, Postdoctoral Research Symposium, Beckman Institute
  • 2018 – Ralph W. and Grace M. Showalter Research Trust Award[18]
  • 2018 – Hanwha Advanced Materials Non-Tenure Faculty Award, Hanhwa Corp., South Korea[19]
  • 2019 – Trailblazer Award for New and Early Stage Investigators – National Institutes of Health (NIH)[20]
  • 2019 – Korean-American Scientists and Engineers Association (KSEA) Young Investigator Award
  • 2019 – Ajouin Outstanding Professional Award, Ajou University, South Korea
  • 2020 – Faculty Award of Excellence for Early Career Research, Purdue University[21]
  • 2020 – Named One of the Most Impactful Faculty Inventors in FY2019-20, Purdue University and OTC
  • 2020 – Ajou Leaders Honor Club Award, Ajou University, South Korea[22]
  • 2021 – Sensors Young Investigator Award, Sensors[23]
  • 2021 – Editor's Award, Journal of Speech, Language, and Hearing Research, ASHA Journal Academy

Bibliography[edit]

  • M. Kim*, C. Kantarcigil*, B. Kim, R. K. Baruah, S. Maity, Y. Park, K. Kim, S. Lee, J. B. Malandraki, A. Avlani, A. Smith, S. Sen, M. A. Alam, G. Malandraki*, C. H. Lee*, Flexible submental sensor patch with remote monitoring controls for management of oropharyngeal swallowing disorders, Science Advances, 5, 12, eaay3210 (2019).
  • B. Kim*, M Kim*, Y. Cho, E. Hamed, M. Gillette, H. Cha, N. Miljkovic, V. Aakalu, K. Kang, K. Son, K. Schachtschneider, L. Schook, C. Hu, G. Popescu, W. Balance, S. Yu, S. Im, J. Lee, C. H. Lee*, H. Kong*, Electrothermal soft manipulator enabling rapid transport and assembly of thin biological sheets and electronic devices, Science Advances, 6, 42, eabc5630 (2020).
  • K. Kim*, H. Kim*, H. Zhang*, W. Park, D. Meyer, M. Kim, B. Kim, H. Park, B. Xu*, P. Kollbaum*, B. Boudouris*, C. H. Lee*, All-printed corneal electrodes on soft contact lenses for noninvasive recording of human electroretinogram, Nature Communications, 12, 1544 (2021)
  • B. Kim*, A. Soepriatna*, W. Park, H. Moon, A. Cox, J. Zhao, N. Gupta, C. Park, K. Kim, Y. Jeon, H. Jang, D. Kim, H. Lee, K. Lee*, C. Goergen*, C. H. Lee*, Rapid custom printing of poroelastic biosensor for simultaneous epicardial recording and imaging, Nature Communications, 12, 3710 (2021)
  • T. Chang*, S. Akins*, M. Kim, L. Murray, Y. Park, S. Cho, S. Hur, L. Couetil*, M. Jun*, C. H. Lee*, Programmable dual regime spray for large-scale and custom-designed electronic textiles, Advanced Materials, 34, 9, 2108021 (2022) – Journal Cover Feature

References[edit]

  1. ^ a b "Chi Hwan Lee - Purdue University".
  2. ^ "Chi Hwan Lee - Google Scholar Profiel".
  3. ^ "Lee, Chi Hwan - Inventions".
  4. ^ "Chi Hwan Lee (ME '07) is known for bringing people—and ideas—together". 8 April 2021.
  5. ^ "DR CHI HWAN LEE - ASSISTANT PROFESSOR, WELDON SCHOOL OF BIOMEDICAL ENGINEERING".
  6. ^ "Take 6: Chi Hwan Lee, College of Engineering". 11 February 2022.
  7. ^ Hwang, Suk-Won; Lee, Chi Hwan; Cheng, Huanyu; Jeong, Jae-Woong; Kang, Seung-Kyun; Kim, Jae-Hwan; Shin, Jiho; Yang, Jian; Liu, Zhuangjian; Ameer, Guillermo A.; Huang, Yonggang; Rogers, John A. (2015). "Biodegradable Elastomers and Silicon Nanomembranes/Nanoribbons for Stretchable, Transient Electronics, and Biosensors". Nano Letters. 15 (5): 2801–2808. Bibcode:2015NanoL..15.2801H. doi:10.1021/nl503997m. PMID 25706246.
  8. ^ Kim, Min Ku; Kantarcigil, Cagla; Kim, Bongjoong; Baruah, Ratul Kumar; Maity, Shovan; Park, Yeonsoo; Kim, Kyunghun; Lee, Seungjun; Malandraki, Jaime Bauer; Avlani, Shitij; Smith, Anne; Sen, Shreyas; Alam, Muhammad A.; Malandraki, Georgia; Lee, Chi Hwan (2019). "Flexible submental sensor patch with remote monitoring controls for management of oropharyngeal swallowing disorders". Science Advances. 5 (12): eaay3210. Bibcode:2019SciA....5.3210K. doi:10.1126/sciadv.aay3210. PMC 6910838. PMID 31853500.
  9. ^ Kim, Hyungjun; Kim, Min Ku; Jang, Hanmin; Kim, Bongjoong; Kim, Dong Rip; Lee, Chi Hwan (2019). "Sensor-Instrumented Scaffold Integrated with Microporous Spongelike Ultrabuoy for Long-Term 3D Mapping of Cellular Behaviors and Functions". ACS Nano. 13 (7): 7898–7904. doi:10.1021/acsnano.9b02291. PMID 31244034. S2CID 195695198.
  10. ^ Kim, Hyungjun; Jang, Hanmin; Kim, Bongjoong; Kim, Min Ku; Wie, Dae Seung; Lee, Heung Soo; Kim, Dong Rip; Lee, Chi Hwan (2018). "Flexible elastomer patch with vertical silicon nanoneedles for intracellular and intratissue nanoinjection of biomolecules". Science Advances. 4 (11): eaau6972. Bibcode:2018SciA....4.6972K. doi:10.1126/sciadv.aau6972. PMC 6226283. PMID 30430139.
  11. ^ Lee, Chi Hwan; Kim, Dong Rip; Zheng, Xiaolin (2011). "Fabrication of Nanowire Electronics on Nonconventional Substrates by Water-Assisted Transfer Printing Method". Nano Letters. 11 (8): 3435–3439. Bibcode:2011NanoL..11.3435L. doi:10.1021/nl201901z. PMID 21696196.
  12. ^ Lee, Chi Hwan; Kim, Dong Rip; Zheng, Xiaolin (2010). "Fabricating nanowire devices on diverse substrates by simple transfer-printing methods". Proceedings of the National Academy of Sciences. 107 (22): 9950–9955. Bibcode:2010PNAS..107.9950L. doi:10.1073/pnas.0914031107. PMC 2890492. PMID 20479263.
  13. ^ Kim, Bong Hoon; Onses, M. Serdar; Lim, Jong Bin; Nam, Sooji; Oh, Nuri; Kim, Hojun; Yu, Ki Jun; Lee, Jung Woo; Kim, Jae-Hwan; Kang, Seung-Kyun; Lee, Chi Hwan; Lee, Jungyup; Shin, Jae Ho; Kim, Nam Heon; Leal, Cecilia; Shim, Moonsub; Rogers, John A. (2015). "High-Resolution Patterns of Quantum Dots Formed by Electrohydrodynamic Jet Printing for Light-Emitting Diodes". Nano Letters. 15 (2): 969–973. Bibcode:2015NanoL..15..969K. doi:10.1021/nl503779e. PMID 25584701.
  14. ^ Wie, Dae Seung; Zhang, Yue; Kim, Min Ku; Kim, Bongjoong; Park, Sangwook; Kim, Young-Joon; Irazoqui, Pedro P.; Zheng, Xiaolin; Xu, Baoxing; Lee, Chi Hwan (2018). "Wafer-recyclable, environment-friendly transfer printing for large-scale thin-film nanoelectronics". Proceedings of the National Academy of Sciences. 115 (31): E7236–E7244. Bibcode:2018PNAS..115E7236W. doi:10.1073/pnas.1806640115. PMC 6077709. PMID 30012591.
  15. ^ Lee, Chi Hwan; Kim, Hojun; Harburg, Daniel V.; Park, Gayoung; Ma, Yinji; Pan, Taisong; Kim, Jae Soon; Lee, Na Yeon; Kim, Bong Hoon; Jang, Kyung-In; Kang, Seung-Kyun; Huang, Yonggang; Kim, Jeongmin; Lee, Kyung-Mi; Leal, Cecilia; Rogers, John A. (2015). "Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants". NPG Asia Materials. 7 (11): e227. doi:10.1038/am.2015.114. PMC 4861403. PMID 27175221. S2CID 6112473.
  16. ^ Koo, Jahyun; et al. (2020). "Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion". Science Advances. 6 (35): eabb1093. Bibcode:2020SciA....6.1093K. doi:10.1126/sciadv.abb1093. PMC 7455185. PMID 32923633.
  17. ^ Zhang, Jinyuan; Xu, Jian; Lim, Jongcheon; Nolan, James K.; Lee, Hyowon; Lee, Chi Hwan (2021). "Wearable Glucose Monitoring and Implantable Drug Delivery Systems for Diabetes Management". Advanced Healthcare Materials. 10 (17): e2100194. doi:10.1002/adhm.202100194. PMID 33930258. S2CID 233471628.
  18. ^ "Ralph W. and Grace M. Showalter Research Trust Award Recipients".
  19. ^ "Non-Tenured Faculty Awards".
  20. ^ "Chi Hwan Lee, Master Collaborator in wearable devices research".
  21. ^ "Chi Hwan Lee receives Early Career Research award".
  22. ^ "Ajou News". 30 August 2019.
  23. ^ "Sensors 2021 Young Investigator Awards".
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