Jean-Pierre Kinet

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Jean-Pierre Kinet (born October 23, 1953) is a French-American immunologist known for his work studying the role of calcium signaling in the immune response.[1] He is a professor in the Department of Pathology and an Immunology Faculty Member in the Beth Israel Deaconess Medical Center at Harvard Medical School.[2]

Kinet was born and raised in Tilff-Esneux, Belgium. and trained as a physician in Belgium. He completed a bachelor's degree in Medicine cum laude from the University of Namur, Belgium, and obtained his M.D. from the University of Liège, Belgium, in 1979. From 1979-1982, he completed a residency in internal medicine, also at the University of Liège, while conducting research in hematology and nephrology.[citation needed]

In 1982, Kinet began a post-doctoral fellowship at the National Institutes of Health (NIH) in the lab of Henry Metzger[3] where he cloned and characterized the alpha subunit of the Fc Receptor for Immunoglobulin E,[4] an important component of the immune response against parasitic infections and the allergic and anaphylactic responses. He then became a senior investigator in 1987 and cloned the beta[5] and gamma subunits of the IgE receptor and show that all subunits were necessary to reconstitute the receptor at the cell surface.[5] In 1989, Kinet was appointed Head of the Molecular Allergy and Immunology Section at the National Institute of Allergy and Infectious Diseases, NIH. His laboratory continued to characterize the biology of the Fc𝛆RI receptor, elucidating key aspects of its gene regulation, antigen recognition, and intracellular signal transduction mechanisms.[6][7] In 1995, Kinet moved to Harvard Medical School, where he was appointed Professor of Pathology.[2] While continuing to investigate Fc𝛆RI biology, his lab also began to study calcium signaling in immune cells. This work eventually led to the identification of key channel proteins involved in calcium signaling in immune and other non-neuronal cell types[8][9][10][11][12]

In the early 2000's, Kinet started collaborating in private biotechnology ventures.[13] He notably co-founded Astarix and AB Science. He is currently chairman for early-stage companie VAXON-Biotech and is Managing Partner in the (€ 50M) iXLife Capital fund.[14] He sits on the board of AB Science SA,[15] Pharmaleads,[16] ONXEO SA,[17] and 6 other companies.[13]

References[edit]

  1. ^ Vig, Monika; Kinet, Jean-Pierre (January 2009). "Calcium signaling in immune cells". Nature Immunology. 10 (1): 21–27. doi:10.1038/ni.f.220. ISSN 1529-2916. PMC 2877033. PMID 19088738.
  2. ^ a b "Harvard Immunology PhD Program". dms.hms.harvard.edu. Retrieved 2018-10-31.
  3. ^ "The American Association of Immunologists - Henry Metzger".
  4. ^ Kinet, J. P.; Metzger, H.; Hakimi, J.; Kochan, J. (1987-07-28). "A cDNA presumptively coding for the .alpha. subunit of the receptor with high affinity for immunoglobulin E". Biochemistry. 26 (15): 4605–4610. doi:10.1021/bi00389a002. ISSN 0006-2960. PMID 2959318.
  5. ^ a b Kinet, J. P.; Blank, U.; Ra, C.; White, K.; Metzger, H.; Kochan, J. (September 1988). "Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E". Proceedings of the National Academy of Sciences of the United States of America. 85 (17): 6483–6487. Bibcode:1988PNAS...85.6483K. doi:10.1073/pnas.85.17.6483. ISSN 0027-8424. PMC 281997. PMID 2970642.
  6. ^ Blank, U.; Ra, C.; Miller, L.; White, K.; Metzger, H.; Kinet, J. P. (1989-01-12). "Complete structure and expression in transfected cells of high affinity IgE receptor". Nature. 337 (6203): 187–189. Bibcode:1989Natur.337..187B. doi:10.1038/337187a0. ISSN 0028-0836. PMID 2521376. S2CID 1830205.
  7. ^ Miller, L.; Blank, U.; Metzger, H.; Kinet, J. P. (1989-04-21). "Expression of high-affinity binding of human immunoglobulin E by transfected cells". Science. 244 (4902): 334–337. Bibcode:1989Sci...244..334M. doi:10.1126/science.2523561. ISSN 0036-8075. PMID 2523561.
  8. ^ Vig, M.; Peinelt, C.; Beck, A.; Koomoa, D. L.; Rabah, D.; Koblan-Huberson, M.; Kraft, S.; Turner, H.; Fleig, A. (2006-05-26). "CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry". Science. 312 (5777): 1220–1223. Bibcode:2006Sci...312.1220V. doi:10.1126/science.1127883. ISSN 1095-9203. PMC 5685805. PMID 16645049.
  9. ^ Launay, Pierre; Cheng, Henrique; Srivatsan, Subhashini; Penner, Reinhold; Fleig, Andrea; Kinet, Jean-Pierre (2004-11-19). "TRPM4 regulates calcium oscillations after T cell activation". Science. 306 (5700): 1374–1377. Bibcode:2004Sci...306.1374L. doi:10.1126/science.1098845. ISSN 1095-9203. PMID 15550671. S2CID 16459097.
  10. ^ Peinelt, Christine; Vig, Monika; Koomoa, Dana L.; Beck, Andreas; Nadler, Monica J. S.; Koblan-Huberson, Murielle; Lis, Annette; Fleig, Andrea; Penner, Reinhold (July 2006). "Amplification of CRAC current by STIM1 and CRACM1 (Orai1)". Nature Cell Biology. 8 (7): 771–773. doi:10.1038/ncb1435. ISSN 1465-7392. PMC 5685802. PMID 16733527.
  11. ^ Vig, Monika; DeHaven, Wayne I.; Bird, Gary S.; Billingsley, James M.; Wang, Huiyun; Rao, Patricia E.; Hutchings, Amy B.; Jouvin, Marie-Hélène; Putney, James W. (January 2008). "Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels". Nature Immunology. 9 (1): 89–96. doi:10.1038/ni1550. ISSN 1529-2916. PMC 2377025. PMID 18059270.
  12. ^ Wang, Huiyun; Zhang, Xuexin; Xue, Li; Xing, Juan; Jouvin, Marie-Hélène; Putney, James W.; Anderson, Matthew P.; Trebak, Mohamed; Kinet, Jean-Pierre (2016-04-19). "Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles". Immunity. 44 (4): 782–794. doi:10.1016/j.immuni.2016.01.015. ISSN 1097-4180. PMC 6771933. PMID 27037192.
  13. ^ a b Bourse, Zone. "Jean-Pierre Kinet - Biographie". www.zonebourse.com (in French). Retrieved 2020-06-12.
  14. ^ "iXLife". iXLife. Retrieved 2020-06-12.
  15. ^ "AB Science - Governance". www.ab-science.com. Retrieved 2020-06-12.
  16. ^ "Board of Directors". Pharmaleads. Retrieved 2020-06-12.
  17. ^ "Jean-Pierre KINET – Onxeo". www.onxeo.com. Retrieved 2020-06-12.
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