Ure2 internal ribosome entry site (IRES)

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In molecular biology, the Ure2 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of Ure2. It allows 5' cap- and eIF4E-independent translation of an N-terminally truncated form of Ure2. This truncated form lacks the prion-forming domain.[1] It is a 104 nucleotide region, smaller than most viral IRES elements, which forms a stem-loop structure.[2] EIF2A represses this IRES resulting in an inhibition of translation of the N-terminally truncated Ure2.[3][4]

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References[edit]

  1. ^ Komar, AA; Lesnik, T; Cullin, C; Merrick, WC; Trachsel, H; Altmann, M (Mar 3, 2003). "Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells". The EMBO Journal. 22 (5): 1199–209. doi:10.1093/emboj/cdg103. PMC 150336. PMID 12606584.
  2. ^ Reineke, LC; Komar, AA; Caprara, MG; Merrick, WC (Jul 4, 2008). "A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae". The Journal of Biological Chemistry. 283 (27): 19011–25. doi:10.1074/jbc.M803109200. PMC 2441550. PMID 18460470.
  3. ^ Komar, AA; Gross, SR; Barth-Baus, D; Strachan, R; Hensold, JO; Goss Kinzy, T; Merrick, WC (Apr 22, 2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A" (PDF). The Journal of Biological Chemistry. 280 (16): 15601–11. doi:10.1074/jbc.M413728200. PMID 15718232.
  4. ^ Reineke, LC; Cao, Y; Baus, D; Hossain, NM; Merrick, WC (2011). "Insights into the role of yeast eIF2A in IRES-mediated translation". PLOS ONE. 6 (9): e24492. Bibcode:2011PLoSO...624492R. doi:10.1371/journal.pone.0024492. PMC 3168509. PMID 21915340.

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