BTF3

BTF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LKX, 3MCB
Identifiers
Aliases	BTF3, BETA-NAC, BTF3a, BTF3b, NACB, basic transcription factor 3
External IDs	OMIM: 602542 MGI: 1202875 HomoloGene: 37453 GeneCards: BTF3
Gene location (Human)
Chr.	Chromosome 5 (human)
End	73,505,667 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	98,453,514 bp
RNA expression pattern
	Top expressed in
	lactiferous duct; ; human penis; ; embryo; ; vulva; ; ganglionic eminence; ; oral cavity; ; trabecular bone; ; endometrium; ; skin of abdomen; ; caput epididymis;
	Top expressed in
	lens; ; ganglionic eminence; ; yolk sac; ; thymus; ; uterus; ; ileum; ; neural tube; ; gonad; ; testicle; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; nucleus; cytosol; nascent polypeptide-associated complex; polysomal ribosome;
Biological process	protein transport; in utero embryonic development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; transport;
	Sources:Amigo / QuickGO
Orthologs
	689
	218490
	ENSG00000145741
	ENSMUSG00000021660
	P20290
	Q64152
	NM_001207; NM_001037637; NM_001393652; NM_001393653
	NM_001170540; NM_145455
	NP_001032726; NP_001198
	NP_001164011; NP_663430
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.^[5]^[6]^[7]^[8]

Function[edit]

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.^[8]

Interactions[edit]

BTF3 has been shown to interact with CSNK2B.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145741 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021660 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zheng XM, Black D, Chambon P, Egly JM (May 1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature. 344 (6266): 556–9. Bibcode:1990Natur.344..556Z. doi:10.1038/344556a0. PMID 2320128. S2CID 4227320.
^ Kanno M, Chalut C, Egly JM (Sep 1992). "Genomic structure of the putative BTF3 transcription factor". Gene. 117 (2): 219–28. doi:10.1016/0378-1119(92)90732-5. PMID 1386332.
^ Freire MA (Apr 2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex". Gene. 345 (2): 271–7. doi:10.1016/j.gene.2004.11.030. PMID 15716105.
^ ^a ^b "Entrez Gene: BTF3 basic transcription factor 3".
^ Grein S, Pyerin W (Jan 1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.

External links[edit]

Human BTF3 genome location and BTF3 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Transcription factor BTF3

Further reading[edit]

Wiedmann B, Sakai H, Davis TA, Wiedmann M (1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature. 370 (6489): 434–40. Bibcode:1994Natur.370..434W. doi:10.1038/370434a0. PMID 8047162. S2CID 4353902.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Grein S, Pyerin W (1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, Hoheise JD, Friess H, Kleeff J (2007). "Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells". Cancer Biol. Ther. 6 (3): 367–76. CiteSeerX 10.1.1.410.5257. doi:10.4161/cbt.6.3.3704. PMID 17312387. S2CID 9044882.
Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, Feneley MR, Patel HR, Patel HR, Masters JR, Ahmed A (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLOS ONE. 8 (12): e84295. Bibcode:2013PLoSO...884295S. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145741 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021660 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2320128-5] Zheng XM, Black D, Chambon P, Egly JM (May 1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature. 344 (6266): 556–9. Bibcode:1990Natur.344..556Z. doi:10.1038/344556a0. PMID 2320128. S2CID 4227320.

[pmid1386332-6] Kanno M, Chalut C, Egly JM (Sep 1992). "Genomic structure of the putative BTF3 transcription factor". Gene. 117 (2): 219–28. doi:10.1016/0378-1119(92)90732-5. PMID 1386332.

[pmid15716105-7] Freire MA (Apr 2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex". Gene. 345 (2): 271–7. doi:10.1016/j.gene.2004.11.030. PMID 15716105.

[entrez-8] "Entrez Gene: BTF3 basic transcription factor 3".

[pmid10094400-9] Grein S, Pyerin W (Jan 1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.

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