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Protein-coding gene in the species Homo sapiens
Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene .[5] [6] [7]
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome , and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.[7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000168438 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038446 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control" . RNA . 4 (10): 1304–12. doi :10.1017/S1355838298980712 . PMC 1369702 PMID 9769104 . ^ Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p" . J Biol Chem . 273 (49): 32771–5. doi :10.1074/jbc.273.49.32771 PMID 9830021 . ^ a b "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)" .
External links [ edit ] Further reading [ edit ]
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