STK16

STK16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BUJ
Identifiers
Aliases	STK16, KRCT, MPSK, PKL12, TSF1, serine/threonine kinase 16, PSK, hPSK
External IDs	OMIM: 604719 MGI: 1313271 HomoloGene: 2739 GeneCards: STK16
EC number	2.7.10.2
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 219,245,455 bp End 219,250,337 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C4 Start 75,187,482 bp End 75,192,250 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right lobe of liver islet of Langerhans stromal cell of endometrium body of stomach right lobe of thyroid gland left lobe of thyroid gland anterior pituitary rectum minor salivary glands Top expressed in superior frontal gyrus spermatocyte yolk sac proximal tubule lip neural tube thymus duodenum cerebellar cortex lateral ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding DNA-binding transcription activator activity, RNA polymerase II-specific non-membrane spanning protein tyrosine kinase activity protein binding ATP binding kinase activity protein serine/threonine kinase activity Cellular component Golgi-associated vesicle perinuclear region of cytoplasm membrane cytoplasm cytosol Biological process protein autophosphorylation peptidyl-tyrosine phosphorylation protein phosphorylation transcription by RNA polymerase II phosphorylation positive regulation of transcription by RNA polymerase II cellular response to transforming growth factor beta stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8576 20872 Ensembl ENSG00000115661 ENSMUSG00000026201 UniProt O75716 O88697 RefSeq (mRNA) NM_001008910 NM_003691 NM_032768 NM_001330213 NM_001330214 NM_001330215 NM_001277992 NM_011494 RefSeq (protein) NP_001008910 NP_001317142 NP_001317143 NP_001317144 NP_001264921 NP_035624 Location (UCSC) Chr 2: 219.25 – 219.25 Mb Chr 1: 75.19 – 75.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 16 is an enzyme that in humans is encoded by the STK16 gene.

Interactions

STK16 has been shown to interact with NAGK.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Berson AE, Young C, Morrison SL, Fujii GH, Sheung J, Wu B, Bolen JB, Burkhardt AL (June 1999). "Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase". Biochemical and Biophysical Research Communications. 259 (3): 533–8. doi:10.1006/bbrc.1999.0811. PMID 10364453.
• Ohta S, Takeuchi M, Deguchi M, Tsuji T, Gahara Y, Nagata K (September 2000). "A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway". The Biochemical Journal. 350 Pt 2 (2): 395–404. doi:10.1042/0264-6021:3500395. PMC 1221266. PMID 10947953.
• Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A (February 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". The Journal of Biological Chemistry. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Guinea B, Ligos JM, Laín de Lera T, Martín-Caballero J, Flores J, Gonzalez de la Peña M, García-Castro J, Bernad A (January 2006). "Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation". Experimental Cell Research. 312 (2): 135–44. doi:10.1016/j.yexcr.2005.10.010. PMID 16310770.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.