Bridging integrator 3

BIN3
Identifiers
Aliases	BIN3, bridging integrator 3
External IDs	OMIM: 606396 MGI: 1929883 HomoloGene: 5472 GeneCards: BIN3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,669,148 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,375,655 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; left adrenal gland; ; oocyte; ; blood; ; right uterine tube; ; stromal cell of endometrium; ; monocyte; ; gallbladder; ; ascending aorta; ; popliteal artery;
	Top expressed in
	spermatocyte; ; secondary oocyte; ; blood; ; spermatid; ; endocardial cushion; ; lip; ; seminiferous tubule; ; spleen; ; thymus; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal anchor activity; protein binding; cytoskeletal protein binding; lipid binding;
Cellular component	cytoplasm; cytoskeleton; actin filament; actin cortical patch;
Biological process	regulation of lamellipodium assembly; unidimensional cell growth; protein localization; division septum assembly; cell cycle; myoblast migration involved in skeletal muscle regeneration; skeletal muscle fiber development; skeletal muscle tissue regeneration; actin filament organization; cell division; cytoskeleton-dependent cytokinesis; endocytosis; actin cortical patch localization; plasma membrane tubulation;
	Sources:Amigo / QuickGO
Orthologs
	55909
	57784
	ENSG00000147439
	ENSMUSG00000022089
	Q9NQY0
	Q9JI08
	NM_018688; NM_001363046
	NM_021328; NM_001360404
	NP_061158; NP_001349975
	NP_067303; NP_001347333
	Wikidata
View/Edit Human	View/Edit Mouse

Bridging integrator 3 is a protein that in humans is encoded by the BIN3 gene.^[5]^[6]

Function[edit]

The product of this gene is a member of the BAR domain protein family. The encoded protein is composed solely of a BAR domain which is predicted to form coiled coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147439 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022089 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ren G, Vajjhala P, Lee JS, Winsor B, Munn AL (Mar 2006). "The BAR domain proteins: molding membranes in fission, fusion, and phagy". Microbiol Mol Biol Rev. 70 (1): 37–120. doi:10.1128/MMBR.70.1.37-120.2006. PMC 1393252. PMID 16524918.
^ ^a ^b "Entrez Gene: BIN3 bridging integrator 3".

External links[edit]

Human BIN3 genome location and BIN3 gene details page in the UCSC Genome Browser.

Further reading[edit]

Habermann B (2004). "The BAR-domain family of proteins: a case of bending and binding?". EMBO Rep. 5 (3): 250–5. doi:10.1038/sj.embor.7400105. PMC 1299016. PMID 14993925.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Routhier EL, Burn TC, Abbaszade I, et al. (2001). "Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p". J. Biol. Chem. 276 (24): 21670–7. doi:10.1074/jbc.M101096200. PMID 11274158.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147439 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022089 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16524918-5] Ren G, Vajjhala P, Lee JS, Winsor B, Munn AL (Mar 2006). "The BAR domain proteins: molding membranes in fission, fusion, and phagy". Microbiol Mol Biol Rev. 70 (1): 37–120. doi:10.1128/MMBR.70.1.37-120.2006. PMC 1393252. PMID 16524918.

[entrez-6] "Entrez Gene: BIN3 bridging integrator 3".

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