PPAP2A

PLPP1
Identifiers
Aliases	PLPP1, LLP1a, LPP1, PAP-2a, PAP2, PPAP2A, phospholipid phosphatase 1
External IDs	OMIM: 607124 HomoloGene: 7484 GeneCards: PLPP1
Gene location (Human) Chr. Chromosome 5 (human) Band 5q11.2 Start 55,424,854 bp End 55,534,969 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder prostate glomerulus metanephric glomerulus left coronary artery right coronary artery mucosa of urinary bladder abdominal fat pericardium saphenous vein n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidate phosphatase activity hydrolase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity phosphatase activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process androgen receptor signaling pathway phospholipid metabolic process regulation of lipid metabolic process protein dephosphorylation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular steroid hormone receptor signaling pathway sphingolipid biosynthetic process germ cell migration negative regulation of cell population proliferation lipid metabolism phospholipid dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8611 n/a Ensembl ENSG00000067113 n/a UniProt O14494 n/a RefSeq (mRNA) NM_003711 NM_176895 n/a RefSeq (protein) NP_003702 NP_795714 n/a Location (UCSC) Chr 5: 55.42 – 55.53 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

Function

Lipid phosphate phosphohydrolase 1 is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• Kanoh H, Kai M, Wada I (1999). "Molecular characterization of the type 2 phosphatidic acid phosphatase". Chem. Phys. Lipids. 98 (1–2): 119–126. doi:10.1016/S0009-3084(99)00024-9. PMID 10358934.
• Nanjundan M, Possmayer F (2003). "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. doi:10.1152/ajplung.00029.2002. PMID 12471011.
• Ulrix W, Swinnen JV, Heyns W, Verhoeven G (1998). "Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP". J. Biol. Chem. 273 (8): 4660–4665. doi:10.1074/jbc.273.8.4660. PMID 9468526.
• Leung DW, Tompkins CK, White T (1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–385. doi:10.1089/dna.1998.17.377. PMID 9570154.
• Hooks SB, Ragan SP, Lynch KR (1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–192. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. S2CID 31610109.
• Roberts R, Sciorra VA, Morris AJ (1998). "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform". J. Biol. Chem. 273 (34): 22059–22067. doi:10.1074/jbc.273.34.22059. PMID 9705349.
• Neumann J, Maas R, Bokník P, et al. (1999). "Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts". J. Pharmacol. Exp. Ther. 289 (1): 188–93. PMID 10087003.
• Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–5263. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
• Roberts RZ, Morris AJ (2001). "Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators". Biochim. Biophys. Acta. 1487 (1): 33–49. doi:10.1016/s1388-1981(00)00081-0. PMID 10962286.
• Woetmann A, Brockdorff J, Lovato P, et al. (2003). "Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling". J. Biol. Chem. 278 (5): 2787–2791. doi:10.1074/jbc.M210196200. PMID 12426308.
• Pandey AV, Mellon SH, Miller WL (2003). "Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17". J. Biol. Chem. 278 (5): 2837–2844. doi:10.1074/jbc.M209527200. PMID 12444089.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Smyth SS, Sciorra VA, Sigal YJ, et al. (2003). "Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity". J. Biol. Chem. 278 (44): 43214–43223. doi:10.1074/jbc.M306709200. PMID 12909631.
• Tanyi JL, Hasegawa Y, Lapushin R, et al. (2004). "Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer". Clin. Cancer Res. 9 (10 Pt 1): 3534–45. PMID 14506139.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grkovich A, Johnson CA, Buczynski MW, Dennis EA (2006). "Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent". J. Biol. Chem. 281 (44): 32978–32987. doi:10.1074/jbc.M605935200. PMID 16950767.
• Kai M, Sakane F, Jia YJ, et al. (2007). "Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts". J. Biochem. 140 (5): 677–686. doi:10.1093/jb/mvj195. PMID 17005594.