EPS8L2

EPS8L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WWU, 1WXB
Identifiers
Aliases	EPS8L2, EPS8R2, EPS8 like 2, DFNB106
External IDs	OMIM: 614988 MGI: 2138828 HomoloGene: 69358 GeneCards: EPS8L2
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 694,438 bp End 727,727 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 140,918,793 bp End 140,942,933 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland minor salivary glands right lobe of liver right uterine tube skin of abdomen amniotic fluid body of pancreas right lung sural nerve Top expressed in intestinal villus esophagus lip duodenum yolk sac ileum jejunum pyloric antrum epithelium of stomach colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding cadherin binding protein binding Cellular component ruffle membrane vesicle plasma membrane extracellular exosome cytoplasm cytosol stereocilium bundle stereocilium tip stereocilium protein-containing complex cell projection Biological process regulation of Rho protein signal transduction Rho protein signal transduction positive regulation of ruffle assembly sensory perception of sound regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64787 98845 Ensembl ENSG00000177106 ENSMUSG00000025504 UniProt Q9H6S3 Q99K30 RefSeq (mRNA) NM_022772 NM_133191 RefSeq (protein) NP_073609 NP_573454 Location (UCSC) Chr 11: 0.69 – 0.73 Mb Chr 7: 140.92 – 140.94 Mb PubMed search
Wikidata
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Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.