Ring finger protein 19B

RNF19B
Identifiers
Aliases	RNF19B, IBRDC3, NKLAM, ring finger protein 19B
External IDs	OMIM: 610872 MGI: 1922484 HomoloGene: 34999 GeneCards: RNF19B
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.1 Start 32,936,445 bp End 32,964,809 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 128,952,064 bp End 128,979,679 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood rectum duodenum appendix smooth muscle tissue gallbladder skin of abdomen jejunal mucosa popliteal artery Top expressed in seminiferous tubule spermatid spermatocyte saccule otic placode cerebellar cortex cerebellar vermis secondary oocyte morula lip More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding ubiquitin protein ligase activity ubiquitin conjugating enzyme binding ubiquitin-protein transferase activity transferase activity ubiquitin binding Cellular component membrane cytolytic granule ubiquitin ligase complex integral component of membrane cytosol endoplasmic reticulum endoplasmic reticulum membrane cytoplasm Biological process positive regulation of proteasomal ubiquitin-dependent protein catabolic process adaptive immune response immune system process protein ubiquitination protein polyubiquitination ubiquitin-dependent protein catabolic process protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127544 75234 Ensembl ENSG00000116514 ENSMUSG00000028793 UniProt Q6ZMZ0 A2A7Q9 RefSeq (mRNA) NM_001127361 NM_001300826 NM_153341 NM_029219 NM_001368763 RefSeq (protein) NP_001120833 NP_001287755 NP_699172 NP_083495 NP_001355692 Location (UCSC) Chr 1: 32.94 – 32.96 Mb Chr 4: 128.95 – 128.98 Mb PubMed search
Wikidata
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Ring finger protein 19B is a protein that in humans is encoded by the RNF19B gene.

Function

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protein is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.