TIPIN

TIPIN
Identifiers
Aliases	TIPIN, TIMELESS interacting protein
External IDs	OMIM: 610716 MGI: 1921571 HomoloGene: 32373 GeneCards: TIPIN
Gene location (Human)
Chr.	Chromosome 15 (human)
End	66,386,746 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	64,212,706 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; secondary oocyte; ; ganglionic eminence; ; islet of Langerhans; ; sperm; ; bone marrow; ; stromal cell of endometrium; ; rectum; ; gastrocnemius muscle; ; right adrenal gland;
	Top expressed in
	medial ganglionic eminence; ; otic placode; ; abdominal wall; ; maxillary prominence; ; somite; ; primitive streak; ; dermis; ; hand; ; saccule; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; DNA binding;
Cellular component	intracellular membrane-bounded organelle; nucleus; nucleoplasm; cytoplasm; replication fork protection complex;
Biological process	cell cycle phase transition; mitotic intra-S DNA damage checkpoint signaling; cellular response to DNA damage stimulus; cell division; DNA replication checkpoint signaling; regulation of nuclear cell cycle DNA replication; positive regulation of cell population proliferation; cell cycle; replication fork arrest; replication fork protection; DNA damage checkpoint signaling; response to UV; DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	54962
	66131
	ENSG00000075131
	ENSMUSG00000032397
	Q9BVW5
	Q91WA1
NM_001289986; NM_017858; NM_001398281; NM_001398282; NM_001398283;
	NM_001398284; NM_001398285; NM_001398286; NM_001398287
	NM_025372; NM_001324556; NM_001324557; NM_001324558
	NP_001276915; NP_060328
	NP_001311485; NP_001311486; NP_001311487; NP_079648
	Wikidata
View/Edit Human	View/Edit Mouse

TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.^[5]^[6]^[7]

Interactions[edit]

TIPIN has been shown to interact with Replication protein A1.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075131 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032397 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology. 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.
^ Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry. 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.
^ "Entrez Gene: TIPIN TIMELESS interacting protein".
^ Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

Further reading[edit]

Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.
Gotter AL, Suppa C, Emanuel BS (Feb 2007). "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors". Journal of Molecular Biology. 366 (1): 36–52. doi:10.1016/j.jmb.2006.10.097. PMC 4151250. PMID 17141802.
Chou DM, Elledge SJ (Nov 2006). "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18143–7. Bibcode:2006PNAS..10318143C. doi:10.1073/pnas.0609251103. PMC 1654129. PMID 17116885.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075131 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032397 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12875843-5] Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology. 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.

[pmid17102137-6] Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry. 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.

[entrez-7] "Entrez Gene: TIPIN TIMELESS interacting protein".

[pmid17296725-8] Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

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