Alison Goate

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Alison Goate
CitizenshipBritish
EducationOxford University (DPhil 1983)
Known forAlzheimer's disease, addiction
AwardsPotamkin Prize (1993)
Metlife Foundation Award (1994)
Alzheimer's Association Lifetime Achievement Award (2015)
Scientific career
FieldsNeurology, Genetics
InstitutionsIcahn School of Medicine
Washington University in St. Louis

Alison Mary Goate is a professor of neuroscience and Director of the Loeb Center for Alzheimer's Disease at Icahn School of Medicine at Mount Sinai, New York City.[1][2] She was previously professor of genetics in psychiatry, professor of genetics, and professor of neurology at Washington University School of Medicine.[3]

The Goate Lab studies the genetics and molecular bases of Alzheimer's disease, frontotemporal dementia, and alcoholism.[4]

Education and early career[edit]

After receiving her undergraduate degree in biochemistry at the University of Bristol (UK) and her graduate training at Oxford University (UK), Goate studied under Professors Theodore Puck, Professor Louis Lim and Dr. John Hardy. She received a Royal Society University Research Fellowship to conduct research at St. Mary's Hospital Medical School in London.[5]

Awards and affiliations[edit]

She has received the Potamkin Prize from the American Academy of Neurology (1993), the Zenith Award from the Alzheimer's Association, Senior Investigator Award from the Metropolitan Life Foundation, the St. Louis Academy of Science Innovation Award, Carl and Gerty Cori Faculty Achievement Award at Washington University in St. Louis. (1994), and a Lifetime Achievement Award from the Alzheimer's Association (2015).[6] She is a fellow of the American Association for the Advancement of Science.[1] She also serves on the faculty of the Hope Center for Neurological Disorders[7] and as an elected member of the National Academy of Medicine.[8]

Research[edit]

Goate's research centers on the genetics of Alzheimer's disease and related dementias that led to the development of animal and cellular models and the development of anti-amyloid and anti-tau therapies. She has been the principal investigator on four grants and has co-invented and awarded six patents.

Patents[edit]

  • APP770 mutant in alzheimer's disease, (1999).[9]
  • Mutant S182 genes, (1999).[10]
  • Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the Alzheimer's S182 gene, (2000).[11]
  • Transgenic mouse expressing an APP-FAD DNA sequence, (2001).[12]
  • Pathogenic Tau mutations, (2002).[13]
  • Markers for addiction, (2011).[14]

Grants[edit]

Partial list:[15]

Funding Source, Project Title & Number Role in Project Dates Direct Costs
JPB Foundation

Identification of Novel Alzheimer's disease genes using next generation sequencing[16]

Principal Investigator 9/1/14-8/31/20 $681,818
NIA

Identification and characterization of AD risk networks using multi-dimensional “omics” data NIA U01 AG052411[17]

Principal Investigator 7/15/16-5/31/21 $871,083
Neurodegeneration Consortium- MD Anderson

Understanding the mechanism of MS4A-dependent AD risk

Principal Investigator 08/07/17-08/06/22 $400,000
NIA

Understanding the mechanism of SPI1 dependent Alzheimer disease risk NIA RF1AG054011[18]

Principal Investigator 8/01/16-6/30/21 $498,389

Publications[edit]

Semantic Scholar lists 483 publications, 22,943 citations and 1,808 influential citations of Goate's peer-reviewed and original contribution as of 2019.[19]

Partial list:

  • Goate, A.; et al. (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. 349 (6311): 704–706. Bibcode:1991Natur.349..704G. doi:10.1038/349704a0. PMID 1671712. S2CID 4336069. Cited by 5017 as of October 18, 2019.[20]
  • De Strooper, B.; et al. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature. 398 (6727): 518–22. Bibcode:1999Natur.398..518D. doi:10.1038/19083. PMID 10206645. S2CID 4346474. Cited by 2274 as of October 18, 2019.[20]
  • Saccone, S. F.; et al. (2007). "Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPS". Human Molecular Genetics. 16 (1): 36–49. doi:10.1093/hmg/ddl438. PMC 2270437. PMID 17135278. Cited by 793 as of October 18, 2019[20]
  • Bierut, L. J.; et al. (2007). "Novel genes identified in a high-density genome wide association study for nicotine dependence". Human Molecular Genetics. 16 (1): 24–35. doi:10.1093/hmg/ddl441. PMC 2278047. PMID 17158188. Cited by 604 as of October 18, 2019.[20]
  • Kehoe, P.; et al. (1999). "A full genome scan for late onset Alzheimer's disease". Human Molecular Genetics. 8 (2): 237–45. doi:10.1093/hmg/8.2.237. PMID 9931331. Cited by 419 as of October 18, 2019[20]
  • Foroud, T.; et al. (2000). "Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping". Alcoholism: Clinical and Experimental Research. 24 (7): 933–45. doi:10.1111/j.1530-0277.2000.tb04634.x. PMID 10923994. Cited by 275 as of October 18, 2019.[20]

[21]==References==

  1. ^ a b "Alison M Goate". Icahn School of Medicine at Mount Sinai. Archived from the original on 23 October 2018. Retrieved 23 October 2018.
  2. ^ "Huffington Center on Aging celebrates 30th anniversary". BCM Family. 5 November 2018. Archived from the original on 18 October 2019. Retrieved 18 October 2019.
  3. ^ Goate, Alison (2008). "Interview". Biomarkers in Medicine. 2 (6). Future Medicine Ltd: 541–545. doi:10.2217/17520363.2.6.541. ISSN 1752-0363. PMID 20477443.
  4. ^ Icahn School of Medicine at Mount Sinai. "Goate Lab". Icahn School of Medicine at Mount Sinai. Archived from the original on 2 September 2019. Retrieved 26 August 2019.
  5. ^ Goate, Alison (December 2008). "Interview". Biomarkers in Medicine. 2 (6): 541–545. doi:10.2217/17520363.2.6.541. PMID 20477443. Archived from the original on 19 October 2019. Retrieved 19 October 2019.
  6. ^ Goate, Alison (2 December 2008). "Interview with Alison Goate". Biomarkers in Medicine. 2 (6): 541–545. doi:10.2217/17520363.2.6.541. ISSN 1752-0371. PMID 20477443.
  7. ^ "Announcements: Bob Lane Receives Lifetime Achievement Award". 1998. doi:10.1037/e404572005-032. {{cite journal}}: Cite journal requires |journal= (help)
  8. ^ "National Academy of Medicine Elects 80 New Members". National Academy of Medicine. 17 October 2016. Archived from the original on 6 January 2017. Retrieved 18 October 2019.
  9. ^ US 5877015, Hardy, John Anthony; Chartier-Harlin, Marie-Christine & Goate, Alison Mary et al., "APP770 mutant in Alzheimer's disease", published 1999-03-02, assigned to Imperial College of Science, Technology and Medicine 
  10. ^ US 5973133, Hardy, John A. & Goate, Alison M., "Mutant S182 genes", published 1999-10-26, assigned to Washington University and University of South Florida 
  11. ^ US 6083694, Hardy, John & Goate, Alison M., "Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the Alzheimer's S182 gene", published 2000-07-04, assigned to Washington University and University of South Florida 
  12. ^ US 6300540, Hardy, John Anthony; Chartier-Harlin, Marie-Christine & Goate, Alison Mary et al., "Transgenic mouse expressing an APP-FAD DNA sequence", published 2001-10-09, assigned to Elan Pharmaceuticals Inc. 
  13. ^ "Espacenet – search results". worldwide.espacenet.com. Archived from the original on 16 March 2023. Retrieved 16 March 2023.
  14. ^ US 8080371, Ballinger, Dennis; Konvicka, Karel & Bierut, Laura Jean et al., "Markers for addiction", published 2011-12-20, assigned to Washington University in St. Louis 
  15. ^ "Alison M. Goate, PhD - US grants". Neurotree. Archived from the original on 16 March 2023. Retrieved 15 September 2019.
  16. ^ "Full text of "Form 990PF" for fiscal year ending Dec. 2017". ProPublica. 9 May 2013. Archived from the original on 16 March 2023. Retrieved 15 September 2019.
  17. ^ Bis, Joshua C.; Jian, Xueqiu; Kunkle, Brian W.; Chen, Yuning; Hamilton-Nelson, Kara L.; Bush, William S.; Salerno, William J.; Lancour, Daniel; Ma, Yiyi; Renton, Alan E.; Marcora, Edoardo; Farrell, John J.; Zhao, Yi; Qu, Liming; Ahmad, Shahzad; Amin, Najaf; Amouyel, Philippe; Beecham, Gary W.; Below, Jennifer E.; Campion, Dominique; Charbonnier, Camille; Chung, Jaeyoon; Crane, Paul K.; Cruchaga, Carlos; Cupples, L. Adrienne; Dartigues, Jean-François; Debette, Stéphanie; Deleuze, Jean-François; Fulton, Lucinda; et al. (2018). "Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation". Molecular Psychiatry. 25 (8). Broad Institute: 1859–1875. doi:10.1038/s41380-018-0112-7. PMC 6375806. PMID 30108311. Archived from the original on 27 June 2020. Retrieved 15 September 2019.
  18. ^ Goate, Alison M.; Marcora, Edoardo; Hao, Ke; Poon, Wayne W.; Roussos, Panos; Bendl, Jaroslav; Fullard, John F.; Cheng, Haoxiang; Efthymiou, Anastasia G.; Abud, Edsel M.; Tcw, Julia; Kapoor, Manav; Novikova, Gloriia (12 August 2019). "Integration of Alzheimer's disease genetics and myeloid genomics reveals novel disease risk mechanisms". bioRxiv. Cold Spring Harbor Laboratory: 694281. doi:10.1101/694281. Archived from the original on 16 March 2023. Retrieved 15 September 2019.
  19. ^ "Alison M. Goate - Semantic Scholar". www.semanticscholar.org. Archived from the original on 18 October 2019. Retrieved 18 October 2019.
  20. ^ a b c d e f "Google Scholar". scholar.google.com. Archived from the original on 16 March 2023. Retrieved 18 October 2019.
  21. ^ Machlovi, Saima (2021). "APOE4 confers transcriptomic and functional alterations to primary mouse microglia". Journal of Neuroscience Research. 99 (1): 9–12. doi:10.1002/jnr.24570. PMC 7754118. PMID 32267025.
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