OTUD1

OTUD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BOP
Identifiers
Aliases	OTUD1, DUBA7, OTDC1, OTU deubiquitinase 1
External IDs	OMIM: 612022 MGI: 1918448 HomoloGene: 45953 GeneCards: OTUD1
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.2 Start 23,439,075 bp End 23,442,377 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 19,662,563 bp End 19,665,394 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle amniotic fluid vena cava body of tongue bronchial epithelial cell superior surface of tongue synovial membrane right ventricle parietal pleura lower lobe of lung Top expressed in ascending aorta aortic valve soleus muscle tibialis anterior muscle quadriceps femoris muscle thoracic diaphragm secondary oocyte digastric muscle ankle temporal muscle More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 220213 71198 Ensembl ENSG00000165312 ENSMUSG00000043415 UniProt Q5VV17 Q9CUB6 RefSeq (mRNA) NM_001145373 NM_027715 RefSeq (protein) NP_001138845 NP_081991 Location (UCSC) Chr 10: 23.44 – 23.44 Mb Chr 2: 19.66 – 19.67 Mb PubMed search
Wikidata
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OTU deubiquitinase 1 is a protein that in humans is encoded by the OTUD1 gene.

Function

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human OTU domain-containing protein 1

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.