Dimetridazole

Dimetridazole
Clinical data
AHFS/Drugs.com	International Drug Names
ATCvet code	QP51AA07 (WHO) ;
Identifiers
	IUPAC name 1,2-dimethyl-5-nitro-1H-imidazole;
CAS Number	551-92-8;
PubChem CID	3090;
ChemSpider	2980 ;
UNII	K59P7XNB8X;
KEGG	D07855 ;
ChEMBL	ChEMBL38938 ;
CompTox Dashboard (EPA)	DTXSID5020497 ;
ECHA InfoCard	100.008.184
Chemical and physical data
Formula	C5H7N3O2
Molar mass	141.130 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ncc([N](=O)=O)n1C;
	InChI InChI=1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3 ; Key:IBXPYPUJPLLOIN-UHFFFAOYSA-N ;
	(verify)

Dimetridazole is a drug that combats protozoan infections. It is a nitroimidazole class drug.^[1] It used to be commonly added to poultry feed. This led to it being found in eggs. Because of suspicions of it being carcinogenic its use has been legally limited but it is still found in the eggs.^[2]^[3] It is now banned as a livestock feed additive in many jurisdictions, for example in the European Union,^[4] Canada.^[5] and the United States.^[6] In the US, the Food and Drug Administration bans it for extralabel use^[7]

References[edit]

^ Dalton, P. (1996). "Use of dimetridazole in gamebirds". The Veterinary Record. 139 (16): 399. PMID 8913016.
^ Posyniak A, Semeniuk S, Zmudzki J, Niedzielska J, Biernacki B (1996). "Residues of dimetridazole in eggs after treatment of laying hens". Veterinary Research Communications. 20 (2): 167–74. doi:10.1007/bf00385638. PMID 8711897. S2CID 38729121.
^ Cannavan A, Kennedy DG (1997). "Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry". The Analyst. 122 (9): 963–6. Bibcode:1997Ana...122..963C. doi:10.1039/a703193i. PMID 9374025.
^ Council Regulation (EEC) No 2377/90 of 26 June 1990 [1]
^ Canadian Food Inspection Agency update Archived May 7, 2005, at the Wayback Machine
^ US Food and Drugs Administration, Food Additives Status List [2]
^ US Food and Drug Administration, Code of Federal Regulations, Title 21, Volume 6, Revised as of April 1, 2020 [3]

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[1] Dalton, P. (1996). "Use of dimetridazole in gamebirds". The Veterinary Record. 139 (16): 399. PMID 8913016.

[2] Posyniak A, Semeniuk S, Zmudzki J, Niedzielska J, Biernacki B (1996). "Residues of dimetridazole in eggs after treatment of laying hens". Veterinary Research Communications. 20 (2): 167–74. doi:10.1007/bf00385638. PMID 8711897. S2CID 38729121.

[3] Cannavan A, Kennedy DG (1997). "Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry". The Analyst. 122 (9): 963–6. Bibcode:1997Ana...122..963C. doi:10.1039/a703193i. PMID 9374025.

[4] Council Regulation (EEC) No 2377/90 of 26 June 1990 [1]

[5] Canadian Food Inspection Agency update Archived May 7, 2005, at the Wayback Machine

[6] US Food and Drugs Administration, Food Additives Status List [2]

[7] US Food and Drug Administration, Code of Federal Regulations, Title 21, Volume 6, Revised as of April 1, 2020 [3]

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