Catherine G Galbraith

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Catherine G Galbraith
NationalityAmerican
Alma mater
Known forCell migration
Super-Resolution Microscopy
Scientific career
FieldsBiophysics
Super-Resolution Microscopy
Institutions
Academic advisorsShu Chien
Richard Skalak
Michael Sheetz
WebsiteGalbraith Lab

Catherine G Galbraith is an American scientist and an Associate Professor of Biomedical Engineering at OHSU and Discovery Engine Investigator at Knight Cancer Institute,[1] known for her work in cell mobility and cell migration as well as super-resolution microscopy. Together with James Galbraith, she heads the Galbraith Lab.[2]

Education[edit]

Galbraith studied Bioengineering at the University of Pennsylvania in Philadelphia, PA, USA. After receiving her BSc in 1985, she attended a Master's program in Bioengineering, which she finished in 1987. Subsequently, Galbraith earned her Ph.D. in Bioengineering in 1995 at University of California, San Diego, CA, USA, advised by Prof Dr Shu Chien.[3][1]

Career and research[edit]

For her postgraduate work between 1995 and 2000, Galbraith worked as a postdoctoral researcher with Prof Dr Michael Sheetz at Duke University in Durham, NC, USA, focusing primarily on cell mobility and migration.[4][5][6][7][8]

Between 2000 and 2013, Galbraith worked at the National Institutes of Health, Bethesda, MD, continuing her work on cell mobility and migration. First as a Research Fellow (2000-2005) and an Independent Senior Researcher (2005-2010) at the National Institute of Dental and Craniofacial Research (NIDCR) and finally as a scientist (2010-2013) at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Between 2010 and 2012, Galbraith was also, for the first time, a visiting scientist at Howard Hughes Medical Institute's Janelia Research Campus.

Collaborations with scientists at Janelia, in particular Eric Betzig and Harald Hess, resulted, amongst others, in key papers that helped to establish the localization-based super-resolution microscopy technique Photoactivated localization microscopy (PALM).[9][10][11][12] Betzig received the Nobel Prize for PALM in 2014.

Since 2013, Galbraith has been an Associate Professor of Biomedical Engineering at OHSU and Discovery Engine Investigator at Knight Cancer Institute.[1]

Together with her husband, James Galbraith, Galbraith uses multidisciplinary approaches and advanced microscopy techniques to explore the mechanisms behind cellular decision-making in a variety of processes, including motility, synaptogenesis, and metastasis.[13][14][15]

Since 2019, Galbraith has also again been a visiting scientist at Howard Hughes Medical Institute's Janelia Research Campus.

Galbraith is a well-known scientist in the field who is frequently invited to speak at conferences, seminars, and workshops.[16][17]

Awards and honours[edit]

  • 2018 - 2024 NIH R01 Grant - "Molecular Mechanisms of Cell Migration"[18]
  • 2017 - 2022 NSF Standard Grant - "Facilitated transport of actin monomer and cytoskeletal remodeling"[19][20]

References[edit]

  1. ^ a b c "Catherine G. Galbraith Ph.D. | OHSU People | OHSU". www.ohsu.edu. Retrieved October 15, 2023.
  2. ^ "Home". Galbraith Lab. Retrieved October 15, 2023.
  3. ^ "About Us". Galbraith Lab. Retrieved October 15, 2023.
  4. ^ Galbraith, Catherine G.; Sheetz, Michael P. (August 19, 1997). "A micromachined device provides a new bend on fibroblast traction forces". Proceedings of the National Academy of Sciences. 94 (17): 9114–9118. Bibcode:1997PNAS...94.9114G. doi:10.1073/pnas.94.17.9114. PMC 23061. PMID 9256444.
  5. ^ Galbraith, C.G.; Skalak, R.; Chien, S. (October 15, 1998). "Shear stress induces spatial reorganization of the endothelial cell cytoskeleton". Cell Motility and the Cytoskeleton. 40 (4): 317–330. doi:10.1002/(SICI)1097-0169(1998)40:4<317::AID-CM1>3.0.CO;2-8. PMID 9712262 – via CrossRef.
  6. ^ Sheetz, Michael P.; Felsenfeld, Dan P.; Galbraith, Catherine G. (February 1, 1998). "Cell migration: regulation of force on extracellular-matrix-integrin complexes". Trends in Cell Biology. 8 (2): 51–54. doi:10.1016/S0962-8924(98)80005-6. PMID 9695809.
  7. ^ Galbraith, Catherine G; Sheetz, Michael P (October 1, 1998). "Forces on adhesive contacts affect cell function". Current Opinion in Cell Biology. 10 (5): 566–571. doi:10.1016/S0955-0674(98)80030-6. PMID 9818165.
  8. ^ Sheetz, M. P.; Felsenfeld, D.; Galbraith, C. G.; Choquet, D. (October 15, 1999). "Cell migration as a five-step cycle". Biochemical Society Symposium. 65: 233–243. PMID 10320942. Retrieved October 15, 2023 – via PubMed.
  9. ^ Shroff, Hari; Galbraith, Catherine G.; Galbraith, James A.; White, Helen; Gillette, Jennifer; Olenych, Scott; Davidson, Michael W.; Betzig, Eric (December 18, 2007). "Dual-color superresolution imaging of genetically expressed probes within individual adhesion complexes". Proceedings of the National Academy of Sciences. 104 (51): 20308–20313. Bibcode:2007PNAS..10420308S. doi:10.1073/pnas.0710517105. PMC 2154427. PMID 18077327.
  10. ^ Shroff, Hari; Galbraith, Catherine G.; Galbraith, James A.; Betzig, Eric (May 15, 2008). "Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics". Nature Methods. 5 (5): 417–423. doi:10.1038/nmeth.1202. PMC 5225950. PMID 18408726.
  11. ^ Shtengel, Gleb; Galbraith, James A.; Galbraith, Catherine G.; Lippincott-Schwartz, Jennifer; Gillette, Jennifer M.; Manley, Suliana; Sougrat, Rachid; Waterman, Clare M.; Kanchanawong, Pakorn; Davidson, Michael W.; Fetter, Richard D.; Hess, Harald F. (March 3, 2009). "Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure". Proceedings of the National Academy of Sciences. 106 (9): 3125–3130. Bibcode:2009PNAS..106.3125S. doi:10.1073/pnas.0813131106. PMC 2637278. PMID 19202073.
  12. ^ Planchon, Thomas A.; Gao, Liang; Milkie, Daniel E.; Davidson, Michael W.; Galbraith, James A.; Galbraith, Catherine G.; Betzig, Eric (May 15, 2011). "Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination". Nature Methods. 8 (5): 417–423. doi:10.1038/nmeth.1586. PMC 3626440. PMID 21378978.
  13. ^ Galbraith, Catherine G.; Keller, Philipp J.; Nogales, Eva (March 15, 2013). "New technologies in imaging". Molecular Biology of the Cell. 24 (6): 669. doi:10.1091/mbc.e12-12-0867. PMC 3596229. PMID 23486393.
  14. ^ Jaqaman, Khuloud; Galbraith, James A.; Davidson, Michael W.; Galbraith, Catherine G. (May 15, 2016). Lippincott-Schwartz, Jennifer (ed.). "Changes in single-molecule integrin dynamics linked to local cellular behavior". Molecular Biology of the Cell. 27 (10): 1561–1569. doi:10.1091/mbc.E16-01-0018. PMC 4865314. PMID 27009207.
  15. ^ Galbraith, James A.; Galbraith, Catherine G. (October 1, 2023). "Using single molecule imaging to explore intracellular heterogeneity". The International Journal of Biochemistry & Cell Biology. 163: 106455. arXiv:2308.01431. doi:10.1016/j.biocel.2023.106455. PMC 10528986. PMID 37586643.
  16. ^ "Cell Biology Seminar: Jim Galbraith and Cathy Galbraith". The Hub. Retrieved October 15, 2023.
  17. ^ Szalinski, Christina (December 1, 2014). "ASCB/IFCB 2014—Looking at Small Things to Understand Big Things". Retrieved October 15, 2023.
  18. ^ "Molecular Mechanisms of Cell Migration". dimensions.ai. Retrieved October 15, 2023.
  19. ^ "NSF Award Search: Award # 1716316 - Facilitated transport of actin monomer and cytoskeletal remodeling". www.nsf.gov. Retrieved October 15, 2023.
  20. ^ "Facilitated transport of actin monomer and cytoskeletal remodeling". dimensions.ai. Retrieved October 15, 2023.
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