HNRNPLL

HNRNPLL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEX, 2E5I
Identifiers
Aliases	HNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDs	OMIM: 611208 MGI: 1919942 HomoloGene: 26701 GeneCards: HNRNPLL
Gene location (Human) Chr. Chromosome 2 (human) Band 2p22.1 Start 38,561,969 bp End 38,603,586 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E3 Start 80,336,916 bp End 80,369,763 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence pancreatic epithelial cell parotid gland saphenous vein bone marrow smooth muscle tissue right uterine tube endothelial cell popliteal artery gastric mucosa Top expressed in medial ganglionic eminence primitive streak abdominal wall somite barrel cortex condyle fossa superior cervical ganglion seminiferous tubule atrium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding mRNA binding nucleic acid binding RNA binding Cellular component membrane nucleus Biological process positive regulation of RNA splicing mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92906 72692 Ensembl ENSG00000143889 ENSMUSG00000024095 UniProt Q8WVV9 Q921F4 RefSeq (mRNA) NM_001142650 NM_138394 NM_144802 RefSeq (protein) NP_001136122 NP_612403 NP_659051 Location (UCSC) Chr 2: 38.56 – 38.6 Mb Chr 17: 80.34 – 80.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.

Further reading

• Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y (November 2011). "Proteomic dissection of the von Hippel-Lindau (VHL) interactome". Journal of Proteome Research. 10 (11): 5175–82. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
• Topp JD, Jackson J, Melton AA, Lynch KW (October 2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA. 14 (10): 2038–49. doi:10.1261/rna.1212008. PMC 2553740. PMID 18719244.
• Wu Z, Yates AL, Hoyne GF, Goodnow CC (July 2010). "Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation". Journal of Immunology. 185 (1): 231–8. doi:10.4049/jimmunol.0903625. PMID 20505149.
• Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA (December 2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications. 416 (3–4): 258–65. doi:10.1016/j.bbrc.2011.10.126. PMID 22079093.
• Shur I, Ben-Avraham D, Benayahu D (June 2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene. 334: 113–21. doi:10.1016/j.gene.2004.03.012. PMID 15256261.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.