Docking protein 6

DOK6
Identifiers
Aliases	DOK6, DOK5L, HsT3226, docking protein 6
External IDs	OMIM: 611402 MGI: 3639495 HomoloGene: 45143 GeneCards: DOK6
Gene location (Human) Chr. Chromosome 18 (human) Band 18q22.2 Start 69,400,888 bp End 69,849,087 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E4 Start 89,310,548 bp End 89,787,652 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 pons endothelial cell middle temporal gyrus ganglionic eminence entorhinal cortex Brodmann area 23 spinal ganglia ventral tegmental area superior frontal gyrus Top expressed in hippocampus proper superior frontal gyrus olfactory bulb hypothalamus cerebellar cortex ganglionic eminence mesencephalon neural tube spinal ganglia trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol Biological process axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 220164 623279 Ensembl ENSG00000206052 ENSMUSG00000073514 UniProt Q6PKX4 Q2MHE5 RefSeq (mRNA) NM_152721 NM_001039173 RefSeq (protein) NP_689934 NP_001034262 Location (UCSC) Chr 18: 69.4 – 69.85 Mb Chr 18: 89.31 – 89.79 Mb PubMed search
Wikidata
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Docking protein 6 is a protein that in humans is encoded by the DOK6 gene.

Function

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).

Further reading

• Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
• Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMID 20210798. S2CID 11769638.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.