TPD52L2

TPD52L2
Identifiers
Aliases	TPD52L2, D54, TPD54, tumor protein D52 like 2, TPD52 like 2
External IDs	OMIM: 603747 MGI: 1913564 HomoloGene: 2469 GeneCards: TPD52L2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,891,545 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,159,759 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; ascending aorta; ; popliteal artery; ; stromal cell of endometrium; ; gastric mucosa; ; left coronary artery; ; smooth muscle tissue; ; left uterine tube; ; monocyte; ; canal of the cervix;
	Top expressed in
	saccule; ; otic placode; ; morula; ; secondary oocyte; ; condyle; ; fossa; ; blastocyst; ; lip; ; endocardial cushion; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; protein heterodimerization activity; RNA binding; catalytic activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm;
Biological process	regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	7165
	66314
	ENSG00000101150
	ENSMUSG00000000827
	O43399; Q6FGS1
	Q9CYZ2
NM_001243891; NM_001243892; NM_001243894; NM_001243895; NM_003288;
	NM_199359; NM_199360; NM_199361; NM_199362; NM_199363
NM_001291197; NM_001291200; NM_001291201; NM_001291202; NM_001291203;
	NM_001291204; NM_025482; NM_001373959; NM_001373960; NM_001373961
NP_001230820; NP_001230821; NP_001230823; NP_001230824; NP_003279;
	NP_955391; NP_955392; NP_955393; NP_955394; NP_955395; NP_003279.2
NP_001278126; NP_001278129; NP_001278130; NP_001278131; NP_001278132;
	NP_001278133; NP_079758; NP_001360888; NP_001360889; NP_001360890; NP_001393282; NP_001393283; NP_001393284; NP_001393285; NP_001393286; NP_001393287; NP_001393288; NP_001393289; NP_001393290; NP_001393291; NP_001393292
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene.^[5]^[6]

Interactions[edit]

TPD52L2 has been shown to interact with TPD52L1^[5] and TPD52.^[5]

Cellular function[edit]

TPD52L2 has a role in membrane traffic.^[7] TPD52L2 is found on small transport vesicles, termed intracellular nanovesicles, that transfer proteins between different cellular compartments. When TPD52L2 is depleted from HeLa cells, the following trafficking pathways are impaired: anterograde traffic, recycling of cargo and Golgi integrity.^[7] Proteomic analysis indicates that TPD52L2 is one of the most abundant proteins expressed in HeLa cells.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000827 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Byrne JA, Nourse CR, Basset P, Gunning P (Mar 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.
^ "Entrez Gene: TPD52L2 tumor protein D52-like 2".
^ ^a ^b Larocque G, La-Borde PJ, Clarke NI, Carter NJ, Royle SJ (2019). "Tumor protein D54 defines a new class of intracellular transport vesicle". J Cell Biol. 219 (1). doi:10.1083/jcb.201812044. PMC 7039206. PMID 31672706.
^ Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M (2017). "A human interactome in three quantitative dimensions organized by stoichiometries and abundances". Cell. 163 (3): 712–23. doi:10.1016/j.cell.2015.09.053. PMID 26496610.

Further reading[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Byrne JA, Mattei MG, Basset P (1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)". Genomics. 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nourse CR, Mattei MG, Gunning P, Byrne JA (1998). "Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts". Biochim. Biophys. Acta. 1443 (1–2): 155–68. doi:10.1016/S0167-4781(98)00211-5. PMID 9838088.
Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
Boutros R, Byrne JA (2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2006). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101150 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000827 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9484778-5] Byrne JA, Nourse CR, Basset P, Gunning P (Mar 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.

[entrez-6] "Entrez Gene: TPD52L2 tumor protein D52-like 2".

[pmid31672706-7] Larocque G, La-Borde PJ, Clarke NI, Carter NJ, Royle SJ (2019). "Tumor protein D54 defines a new class of intracellular transport vesicle". J Cell Biol. 219 (1). doi:10.1083/jcb.201812044. PMC 7039206. PMID 31672706.

[pmid26496610-8] Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M (2017). "A human interactome in three quantitative dimensions organized by stoichiometries and abundances". Cell. 163 (3): 712–23. doi:10.1016/j.cell.2015.09.053. PMID 26496610.

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