DTYMK

DTYMK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E9F, 1E9E, 1NMY, 1E2G, 1E9D, 1E98, 1E2E, 1NN0, 1E2Q, 1E9C, 1E2F, 1NN5, 1E99, 2XX3, 1NMZ, 1E9A, 1E2D, 1E9B, 1NMX, 1NN1, 1NN3
Identifiers
Aliases	DTYMK, CDC8, PP3731, TMPK, TYMK, deoxythymidylate kinase, CONPM
External IDs	OMIM: 188345 MGI: 108396 HomoloGene: 6285 GeneCards: DTYMK
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 241,675,747 bp End 241,686,944 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 D|1 47.34 cM Start 93,720,298 bp End 93,729,656 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence stromal cell of endometrium right adrenal gland left adrenal gland right lobe of liver spleen lymph node body of stomach skin of abdomen canal of the cervix Top expressed in endocardial cushion renal corpuscle primitive streak medullary collecting duct Paneth cell ureter condyle fossa yolk sac vas deferens More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding uridylate kinase activity kinase activity thymidylate kinase activity nucleoside monophosphate kinase activity ATP binding nucleoside diphosphate kinase activity Cellular component mitochondrial intermembrane space mitochondrial matrix cytoplasm mitochondrion cytosol nucleus Biological process nucleobase-containing small molecule interconversion nucleotide biosynthetic process response to cadmium ion phosphorylation cellular response to growth factor stimulus dTTP biosynthetic process response to estrogen dTDP biosynthetic process dUDP biosynthetic process myoblast differentiation cell population proliferation nucleoside monophosphate phosphorylation nucleotide phosphorylation nucleoside diphosphate phosphorylation thymidine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1841 21915 Ensembl ENSG00000168393 ENSMUSG00000026281 UniProt P23919 P97930 RefSeq (mRNA) NM_001165031 NM_012145 NM_001320902 NM_001320903 NM_001320904 NM_001320905 NM_001105667 NM_023136 RefSeq (protein) NP_001158503 NP_001307831 NP_001307832 NP_001307833 NP_001307834 NP_036277 NP_001099137 NP_075625 Location (UCSC) Chr 2: 241.68 – 241.69 Mb Chr 1: 93.72 – 93.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene. and belongs to thymidylate kinase family of proteins.

Further reading

• Van Rompay AR, Johansson M, Karlsson A (2000). "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases". Pharmacol. Ther. 87 (2–3): 189–98. doi:10.1016/S0163-7258(00)00048-6. PMID 11008000.
• Tamiya N, Yusa T, Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography". Biochim. Biophys. Acta. 995 (1): 28–35. doi:10.1016/0167-4838(89)90229-X. PMID 2538159.
• Cummins RR, Balinsky D (1980). "Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver". Cancer Res. 40 (4): 1235–9. PMID 6244089.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ostermann N, Segura-Peña D, Meier C, et al. (2003). "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds". Biochemistry. 42 (9): 2568–77. doi:10.1021/bi027302t. PMID 12614151.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.