Ae binding protein 1

AEBP1
Identifiers
Aliases	AEBP1, ACLP, AE binding protein 1
External IDs	OMIM: 602981 MGI: 1197012 HomoloGene: 878 GeneCards: AEBP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,114,562 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,822,088 bp
RNA expression pattern
	Top expressed in
	thoracic aorta; ; ascending aorta; ; right coronary artery; ; popliteal artery; ; left coronary artery; ; saphenous vein; ; canal of the cervix; ; gallbladder; ; left uterine tube; ; gastric mucosa;
	Top expressed in
	ascending aorta; ; aortic valve; ; calvaria; ; uterus; ; cervix; ; body of femur; ; adrenal gland; ; intercostal muscle; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; zinc ion binding; calmodulin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; metallocarboxypeptidase activity; carboxypeptidase activity; serine-type carboxypeptidase activity; extracellular matrix structural constituent; collagen binding;
Cellular component	cytoplasm; extracellular matrix; extracellular exosome; nucleus; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	skeletal system development; regulation of transcription, DNA-templated; peptide metabolic process; protein processing; muscle organ development; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; proteolysis; regulation of collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
	165
	11568
	ENSG00000106624
	ENSMUSG00000020473
	Q8IUX7
	Q640N1
	NM_001129
	NM_001291857; NM_009636
	NP_001120
	NP_001278786; NP_033766
	Wikidata
View/Edit Human	View/Edit Mouse

AE binding protein 1 is a protein that in humans is encoded by the AEBP1 gene.^[5]

Function[edit]

AE binding protein 1 is a member of carboxypeptidase A protein family. The protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that the AEBP1 gene that encodes the protein functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106624 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020473 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: AE binding protein 1".

External links[edit]

Human AEBP1 genome location and AEBP1 gene details page in the UCSC Genome Browser.

Further reading[edit]

Tumelty KE, Smith BD, Nugent MA, Layne MD (2014). "Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor β receptor-dependent and -independent pathways". Journal of Biological Chemistry. 289 (5): 2526–36. doi:10.1074/jbc.M113.502617. PMC 3908388. PMID 24344132.
Lyons PJ, Muise AM, Ro HS (2005). "MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1". Biochemistry. 44 (3): 926–31. doi:10.1021/bi0480178. PMID 15654748.
Majdalawieh A, Ro HS (2010). "PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1". Nuclear Receptor Signaling. 8: e004. doi:10.1621/nrs.08004. PMC 2858268. PMID 20419060.
Muise AM, Ro HS (1999). "Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: Stimulation of enzymic activity by its target DNA". The Biochemical Journal. 343 (2): 341–5. doi:10.1042/0264-6021:3430341. PMC 1220559. PMID 10510298.
Feldkamp ML, Bowles NE, Botto LD (2012). "AEBP1 gene variants in infants with gastroschisis". Birth Defects Research Part A: Clinical and Molecular Teratology. 94 (9): 738–42. doi:10.1002/bdra.23041. PMID 22821744.
Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME (2001). "Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein". Molecular and Cellular Biology. 21 (15): 5256–61. doi:10.1128/MCB.21.15.5256-5261.2001. PMC 87249. PMID 11438679.
Ohno I, Hashimoto J, Shimizu K, Takaoka K, Ochi T, Matsubara K, Okubo K (1996). "A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line". Biochemical and Biophysical Research Communications. 228 (2): 411–4. doi:10.1006/bbrc.1996.1675. PMID 8920928.
Majdalawieh A, Ro HS (2010). "Regulation of Ikappa Balpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages". Mediators of Inflammation. 2010: 823821. doi:10.1155/2010/823821. PMC 2855089. PMID 20396415.
Song L, Fricker LD (1997). "Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase". The Journal of Biological Chemistry. 272 (16): 10543–50. doi:10.1074/jbc.272.16.10543. PMID 9099699.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106624 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020473 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AE binding protein 1".

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