George Stouffer

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George "Rick" Stouffer
OccupationChief of Cardiology at UNC Medical Center

George "Rick" Stouffer is an American cardiologist who is Chief of the Division of Cardiology at the University of North Carolina Medical Center,[1] where he is a practicing interventional cardiologist.[2] Stouffer was awarded the Ernest and Hazel Craige Distinguished Professorship of Medicine in 2018; prior to that he was the Henry A. Foscue Distinguished Professor of Medicine.[3] Stouffer is also co-director of the McAllister Heart Institute.[4] He is known for his research regarding inpatient ST elevation myocardial infarctions.[5]

Education and Training[edit]

Stouffer attended Bucknell University and graduated magna cum laude in 1980. During his time at Bucknell, Stouffer was inducted into both the Phi Beta Kappa and Tau Beta Pi honor societies.[6] Stouffer attended the University of Maryland School of Medicine and was inducted into the Alpha Omega Alpha honor society.[6] He completed his postgraduate medical training at the University of Virginia between 1987 and 1995. Throughout these eight years he completed his internal medicine residency, his cardiovascular research fellowship, his clinical cardiology fellowship, and his interventional cardiology fellowship.[6]

Professional career[edit]

Stouffer was on the faculty at the University of Texas Medical Branch in Galveston, Texas from 1995-2000.[7][2] In 2000, Stouffer moved to UNC and was awarded the Henry A. Foscue Distinguished Professor of Medicine in 2005, and later awarded the Ernest and Hazel Craige Distinguished Professor of Medicine in 2018.[2] From 2001-2016 he was the Director of the Cardiac Catheterization Laboratories and the Director of Interventional Cardiology.[2] He was appointed Chief of the Division of Cardiology in 2013.[2]

Research and publications[edit]

Stouffer has published in journals such as the Journal of the American Medical Association (JAMA), Journal of the American College of Cardiology (JACC), Circulation, Nature Reviews, JAMA-Cardiology, the Journal of the American Heart Association (JAHA), Journal of Investigative Medicine (JIM), American Heart Journal, American Journal of the Medical Sciences, Journal of Vascular Medicine and Biology and Transactions of the American Clinical and Climatological Association.[6] He serves on the Editorial Boards of JACC-Cardiovascular Interventions and the American Journal of Cardiology. One focus of Stouffer’s recent clinical research is on patients who have a ST elevation myocardial infarction (STEMI) while hospitalized for a non-cardiac condition.[8][9][10][11][12][13] Stouffer’s group has published the largest study on "inpatient" STEMIs and also developed a quality improvement program to expedite treatment of these patients.[5] Stouffer was the senior author on a study that was featured in the Wall Street Journal in 2015.[5]

Another focus of Stouffer's clinical research is on using CYP2C19 genotyping to identify the best anti-platelet agent for patients with acute coronary syndromes and/or undergoing percutaneous coronary intervention.[14][15][16][17] Stouffer’s laboratory has a long-standing interest in understanding the direct effects of thrombin on smooth muscle cells (SMC).[18][19][20][21] Stouffer’s laboratory is also interested in the role that β3 integrins play in mediating SMC responses to thrombin. His studies have focused on identifying mechanisms whereby β3 integrins mediate responses to thrombin and other SMC agonists.[22][23][24][25]

Stouffer’s early studies examined the mechanisms by which soluble growth factors stimulate smooth muscle cell proliferation.[26][27][28][29][30]

Textbooks[edit]

Stouffer has published three textbooks: Cardiology Board Review: ECG, Hemodynamic and Angiographic Unknowns (2019); Practical ECG Interpretation: Clues to Heart Disease in Young Adults (2009); and Cardiovascular Hemodynamics for the Clinician (2008; second edition in 2017).[6] He was an editor for the second (2010) and third (2019) editions of Netter’s Cardiology along with Marschall S. Runge M.D., Cam Patterson M.D. and Joseph S. Rossi M.D. This book utilizes artwork from the famous medical illustrator, the late Frank H. Netter, to provide an overview of cardiovascular anatomy, pathophysiology, diagnosis and management.[31]

Personal life[edit]

Stouffer lives in Chapel Hill. He and his wife, Meg, have four adult children.[32]

References[edit]

  1. ^ "Faculty & Administration". Department of Medicine.
  2. ^ a b c d e "Rick Stouffer, MD". Department of Medicine.
  3. ^ "Rick Stouffer Is Appointed Ernest and Hazel Craige Distinguished Professor". Department of Medicine. March 7, 2018.
  4. ^ "New Leadership for McAllister Heart Institute Announced — News Room - UNC Health Care" – via news.unchealthcare.org.
  5. ^ a b c Winslow, Ron (February 2, 2015). "The Hospital Is No Place for a Heart Attack". Wall Street Journal – via www.wsj.com.
  6. ^ a b c d e "George A. Stouffer, III" (PDF). Archived from the original (PDF) on 2019-12-23. Retrieved 2019-12-23.
  7. ^ "Stouffer appointed Ernest and Hazel Craige Distinguished Professor — News Room - UNC Health and UNC School of Medicine" – via news.unchealthcare.org.
  8. ^ Dai, Xuming; Bumgarner, Joseph; Spangler, Andrew; Meredith, Dane; Smith, Sidney C.; Stouffer, George A. (April 4, 2013). "Acute ST-elevation myocardial infarction in patients hospitalized for noncardiac conditions". Journal of the American Heart Association. 2 (2): e000004. doi:10.1161/JAHA.113.000004. PMC 3647284. PMID 23557748.
  9. ^ Kaul, Prashant; Federspiel, Jerome J.; Dai, Xuming; Stearns, Sally C.; Smith, Sidney C.; Yeung, Michael; Beyhaghi, Hadi; Zhou, Lei; Stouffer, George A. (November 19, 2014). "Association of inpatient vs outpatient onset of ST-elevation myocardial infarction with treatment and clinical outcomes". JAMA. 312 (19): 1999–2007. doi:10.1001/jama.2014.15236. PMC 4266685. PMID 25399275.
  10. ^ Dai, Xuming; Kaul, Prashant; Smith, Sidney C.; Stouffer, George A. (March 23, 2016). "Predictors, treatment, and outcomes of STEMI occurring in hospitalized patients". Nature Reviews. Cardiology. 13 (3): 148–154. doi:10.1038/nrcardio.2015.165. PMID 26525542. S2CID 24945828.
  11. ^ Dai, Xuming; Meredith, Dane; Sawey, Edward; Kaul, Prashant; Smith, Sidney C.; Stouffer, George A. (December 1, 2016). "A Quality Improvement Program for Recognition and Treatment of Inpatient ST-Segment Elevation Myocardial Infarctions". JAMA Cardiology. 1 (9): 1077–1079. doi:10.1001/jamacardio.2016.3031. PMID 27652519 – via jamanetwork.com.
  12. ^ Levine, G. N.; Dai, X.; Henry, T. D.; Calfon Press, M.; Denktas, A. E.; Garberich, R. F.; Jacobs, A. K.; Jaski, B. E.; Kaul, P.; Kontos, M. C.; Stouffer, G. A.; Smith Jr, S. C.; In-Hospital STEMI Quality Improvement Project (June 1, 2018). "In-Hospital ST-Segment Elevation Myocardial Infarction: Improving Diagnosis, Triage, and Treatment". JAMA Cardiology. 3 (6): 527–531. doi:10.1001/jamacardio.2017.5356. PMID 29466558. S2CID 40797414.
  13. ^ Tahir, Khola; Pauley, Eric; Dai, Xuming; Smith, Sidney C.; Sweeney, Craig; Stouffer, George A. (May 1, 2019). "Mechanisms of ST Elevation Myocardial Infarction in Patients Hospitalized for Noncardiac Conditions". The American Journal of Cardiology. 123 (9): 1393–1398. doi:10.1016/j.amjcard.2019.01.039. PMID 30773247. S2CID 73456569.
  14. ^ Rossi, J. S.; Cammarata, M.; Dharmavaram, J.; Weck, K.; Walko, C.; Gabriel, D.; Kuritzky, J.; Muldrew, K.; Stouffer, G. A. (2014). "Clopidogrel dose adjustment after outpatient screening for CYP2C19 variant alleles: a pilot study. - PubMed - NCBI". Pharmacogenomics. 15 (7): 915–23. doi:10.2217/pgs.14.17. PMID 24956245.
  15. ^ Lee, John Andrew; Lee, Craig R.; Reed, Brent N.; Plitt, David C.; Polasek, Melissa J.; Howell, Lucius A.; Cicci, Jonathan D.; Tasca, Kristen E.; Weck, Karen E.; Rossi, Joseph S.; Stouffer, George A. (December 23, 2015). "Implementation and evaluation of a CYP2C19 genotype-guided antiplatelet therapy algorithm in high-risk coronary artery disease patients". Pharmacogenomics. 16 (4): 303–313. doi:10.2217/pgs.14.180. PMID 25823779.
  16. ^ Cavallari, L. H.; Lee, C. R.; Beitelshees, A. L.; Cooper-Dehoff, R. M.; Duarte, J. D.; Voora, D.; Kimmel, S. E.; McDonough, C. W.; Gong, Y.; Dave, C. V.; Pratt, V. M.; Alestock, T. D.; Anderson, R. D.; Alsip, J.; Ardati, A. K.; Brott, B. C.; Brown, L.; Chumnumwat, S.; Clare-Salzler, M. J.; Coons, J. C.; Denny, J. C.; Dillon, C.; Elsey, A. R.; Hamadeh, I. S.; Harada, S.; Hillegass, W. B.; Hines, L.; Horenstein, R. B.; Howell, L. A.; et al. (January 22, 2018). "Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention". JACC. Cardiovascular Interventions. 11 (2): 181–191. doi:10.1016/j.jcin.2017.07.022. PMC 5775044. PMID 29102571.
  17. ^ Lee, Craig R.; Sriramoju, Vindhya B.; Cervantes, Alexandra; Howell, Lucius A.; Varunok, Nicholas; Madan, Shivanshu; Hamrick, Kasey; Polasek, Melissa J.; Lee, John Andrew; Clarke, Megan; Cicci, Jonathan D.; Weck, Karen E.; Stouffer, George A. (April 23, 2018). "Clinical Outcomes and Sustainability of Using CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention". Circulation: Genomic and Precision Medicine. 11 (4): e002069. doi:10.1161/CIRCGEN.117.002069. PMC 5889089. PMID 29615454.
  18. ^ Stouffer, G. A.; Sarembock, I. J.; McNamara, C. A.; Gimple, L. W.; Owens, G. K. (September 23, 1993). "Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA". The American Journal of Physiology. 265 (3 Pt 1): C806–811. doi:10.1152/ajpcell.1993.265.3.C806. PMID 8214037.
  19. ^ Stouffer, G. A.; Runge, M. S. (1996). "Europe PMC". Journal of the American College of Cardiology. 28 (7): 1856–1857. doi:10.1016/S0735-1097(96)00416-0. PMID 8962576.
  20. ^ Stouffer, G. A.; Smyth, S. S. (November 1, 2003). "Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 23 (11): 1971–1978. doi:10.1161/01.ATV.0000093470.51580.0F. PMID 12947018.
  21. ^ Sajid, M.; Zhao, R.; Pathak, A.; Smyth, S. S.; Stouffer, G. A. (November 23, 2003). "Alphavbeta3-integrin antagonists inhibit thrombin-induced proliferation and focal adhesion formation in smooth muscle cells". American Journal of Physiology. Cell Physiology. 285 (5): C1330–1338. doi:10.1152/ajpcell.00475.2002. PMID 12878490. S2CID 86265635.
  22. ^ Stouffer, G. A.; Hu, Z.; Sajid, M.; Li, H.; Jin, G.; Nakada, M. T.; Hanson, S. R.; Runge, M. S. (March 10, 1998). "Beta3 integrins are upregulated after vascular injury and modulate thrombospondin- and thrombin-induced proliferation of cultured smooth muscle cells". Circulation. 97 (9): 907–915. doi:10.1161/01.cir.97.9.907. PMID 9521340.
  23. ^ Estevez, Brian; Shen, Bo; Du, Xiaoping (January 23, 2015). "Targeting Integrin and Integrin Signaling in Treating Thrombosis". Arteriosclerosis, Thrombosis, and Vascular Biology. 35 (1): 24–29. doi:10.1161/ATVBAHA.114.303411. PMC 4270936. PMID 25256236.
  24. ^ Silva, Rita; d'Amico, Gabriela; Hodivala-Dilke, Kairbaan M.; Reynolds, Louise E. (October 1, 2008). "Integrins". Arteriosclerosis, Thrombosis, and Vascular Biology. 28 (10): 1703–1713. doi:10.1161/ATVBAHA.108.172015. PMID 18658045.
  25. ^ Pathak, Alokkumar; Zhao, Renyi; Huang, Jianhua; Stouffer, George A. (December 23, 2008). "Eptifibatide and abciximab inhibit insulin-induced focal adhesion formation and proliferative responses in human aortic smooth muscle cells". Cardiovascular Diabetology. 7: 36. doi:10.1186/1475-2840-7-36. PMC 2628888. PMID 19108709.
  26. ^ "Rick A. Stouffer". eventscribe.com.
  27. ^ Stouffer, G. A.; Owens, G. K. (April 23, 1992). "Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta". Circulation Research. 70 (4): 820–828. doi:10.1161/01.res.70.4.820. PMID 1551205.
  28. ^ Stouffer, G. A.; LaMarre, J.; Gonias, S. L.; Owens, G. K. (August 25, 1993). "Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response". The Journal of Biological Chemistry. 268 (24): 18340–18344. doi:10.1016/S0021-9258(17)46850-5. PMID 7688745.
  29. ^ Stouffer, G A; Owens, G K (May 23, 1994). "TGF-beta promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms". Journal of Clinical Investigation. 93 (5): 2048–2055. doi:10.1172/JCI117199. PMC 294321. PMID 8182136.
  30. ^ McNamara, C. A.; Sarembock, I. J.; Bachhuber, B. G.; Stouffer, G. A.; Ragosta, M.; Barry, W.; Gimple, L. W.; Powers, E. R.; Owens, G. K. (December 23, 1996). "Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosis". Seminars in Thrombosis and Hemostasis. 22 (2): 139–144. doi:10.1055/s-2007-999001. PMID 8807710.
  31. ^ Netter's Cardiology. Saunders. 27 July 2010.
  32. ^ "Our Leadership – PAPA Missions".
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