Integrator complex subunit 5

INTS5
Identifiers
Aliases	INTS5, INT5, KIAA1698, integrator complex subunit 5
External IDs	OMIM: 611349 MGI: 1923578 HomoloGene: 35303 GeneCards: INTS5
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.3 Start 62,646,848 bp End 62,653,302 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 8,870,369 bp End 8,875,252 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gastrocnemius muscle islet of Langerhans right adrenal gland right lobe of liver left adrenal gland popliteal artery left uterine tube body of stomach skin of abdomen Top expressed in corneal stroma renal corpuscle primitive streak maxillary prominence internal carotid artery neural tube yolk sac somite lip lacrimal gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integrator complex integral component of membrane membrane nucleus nucleoplasm nuclear membrane cytoplasm Biological process snRNA processing snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80789 109077 Ensembl ENSG00000185085 ENSMUSG00000071652 UniProt Q6P9B9 Q8CHT3 RefSeq (mRNA) NM_030628 NM_176843 RefSeq (protein) NP_085131 NP_789813 Location (UCSC) Chr 11: 62.65 – 62.65 Mb Chr 19: 8.87 – 8.88 Mb PubMed search
Wikidata
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Integrator complex subunit 5 is a protein that in humans is encoded by the INTS5 gene.

Function

The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.