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In molecular biology, the EAF family of proteins act as transcriptional transactivators of ELL and ELL2 RNA Polymerase II (Pol II) transcriptional elongation factors .[1] [2] [3] proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. ELL and EAF1 are components of Cajal bodies , which have a role in leukemogenesis .[2] interact with ELL1 and ELL2. The N terminus of approx 120 of EAF1 has a region of high serine , aspartic acid , and glutamic acid residues .[1] [4]
References [ edit ]
^ a b Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein". Blood . 98 (1): 201–9. doi :10.1182/blood.V98.1.201 . PMID 11418481 . S2CID 2577367 . ^ a b Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003). "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia" . Mol. Biol. Cell . 14 (4): 1517–28. doi :10.1091/mbc.E02-07-0394 . PMC 153119 PMID 12686606 . ^ Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL" . Proc. Natl. Acad. Sci. U.S.A . 102 (29): 10094–8. Bibcode :2005PNAS..10210094K . doi :10.1073/pnas.0503017102 PMC 1177379 PMID 16006523 . ^ Banks CA, Kong SE, Spahr H, Florens L, Martin-Brown S, Washburn MP, Conaway JW, Mushegian A, Conaway RC (February 2007). "Identification and Characterization of a Schizosaccharomyces pombe RNA Polymerase II Elongation Factor with Similarity to the Metazoan Transcription Factor ELL" . J. Biol. Chem . 282 (8): 5761–9. doi :10.1074/jbc.M610393200 PMID 17150956 .
