NUDT11

NUDT11
Identifiers
Aliases	NUDT11, APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta, nudix hydrolase 11
External IDs	OMIM: 300528 MGI: 1930957 HomoloGene: 86995 GeneCards: NUDT11
EC number	3.6.1.60
Gene location (Human) Chr. X chromosome (human) Band Xp11.22 Start 51,490,011 bp End 51,496,592 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A1.1 Start 5,959,507 bp End 5,967,164 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in orbitofrontal cortex Brodmann area 23 embryo ganglionic eminence middle temporal gyrus superior frontal gyrus oocyte secondary oocyte Brodmann area 46 nucleus accumbens Top expressed in arcuate nucleus dorsomedial hypothalamic nucleus median eminence ventromedial nucleus suprachiasmatic nucleus paraventricular nucleus of hypothalamus barrel cortex supraoptic nucleus yolk sac ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity hydrolase activity metal ion binding inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity endopolyphosphatase activity diphosphoinositol-polyphosphate diphosphatase activity bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity m7G(5')pppN diphosphatase activity Cellular component intracellular anatomical structure nucleus cytoplasm cytosol Biological process inositol phosphate metabolic process diphosphoinositol polyphosphate metabolic process diadenosine pentaphosphate catabolic process diadenosine hexaphosphate catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55190 58242 Ensembl ENSG00000196368 ENSMUSG00000073295 UniProt Q96G61 P0C027 P0C028 RefSeq (mRNA) NM_018159 NM_021431 RefSeq (protein) NP_060629 NP_001026834 NP_067406 NP_067406 Location (UCSC) Chr X: 51.49 – 51.5 Mb Chr X: 5.96 – 5.97 Mb PubMed search
Wikidata
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Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.

NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002).[supplied by OMIM]

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Leslie NR, McLennan AG, Safrany ST (2002). "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases". BMC Biochem. 3: 20. doi:10.1186/1471-2091-3-20. PMC 117780. PMID 12121577.
• Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.