HEPN1

HEPN1
Identifiers
Aliases	HEPN1, hepatocellular carcinoma, down-regulated 1
External IDs	OMIM: 611641 HomoloGene: 134601 GeneCards: HEPN1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	124,920,677 bp
RNA expression pattern
	Top expressed in
	amygdala; ; putamen; ; substantia nigra; ; caudate nucleus; ; nucleus accumbens; ; hippocampus proper; ; prefrontal cortex; ; cerebellum;
	n/a
	More reference expression data
	n/a
Orthologs
	641654
	n/a
	ENSG00000221932
	n/a
	Q6WQI6
	n/a
	NM_001037558
	n/a
	NP_001032647
	n/a
	Wikidata
View/Edit Human

Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. ^[3]

Function[edit]

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes.^[4] Also to note is that this gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221932 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Hepatocellular carcinoma, down-regulated 1". Retrieved 2017-09-12.
^ Moh MC, Lee LH, Yang X, Shen S (2003). "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells". J Hepatol. 39 (4): 580–6. doi:10.1016/s0168-8278(03)00359-3. PMID 12971969.
^ Chung Moh M, Hoon Lee L, Shen S (2005). "Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma". J Hepatol. 42 (6): 833–41. doi:10.1016/j.jhep.2005.01.025. PMID 15885354.

Further reading[edit]

Peng H, Fan J, Wu J, Lang J, Wang J, Liu H, Zhao S, Liao J (2013). "Silencing of HEPN1 is responsible for the aggressive biological behavior of pituitary somatotroph adenomas". Cell. Physiol. Biochem. 31 (2–3): 379–88. doi:10.1159/000343375. PMID 23548416.
Kim HS, Jung G (2014). "Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor". FEBS Lett. 588 (23): 4413–21. doi:10.1016/j.febslet.2014.10.011. PMID 25448679. S2CID 859229.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221932 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Hepatocellular carcinoma, down-regulated 1". Retrieved 2017-09-12.

[4] Moh MC, Lee LH, Yang X, Shen S (2003). "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells". J Hepatol. 39 (4): 580–6. doi:10.1016/s0168-8278(03)00359-3. PMID 12971969.

[5] Chung Moh M, Hoon Lee L, Shen S (2005). "Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma". J Hepatol. 42 (6): 833–41. doi:10.1016/j.jhep.2005.01.025. PMID 15885354.

[1]

[2]

[3]

[4]

[5]