WDR45L

WDR45B
Identifiers
Aliases	WDR45B, WDR45L, WIPI-3, WIPI3, WD repeat domain 45B, NEDSBAS
External IDs	OMIM: 609226 MGI: 1914090 HomoloGene: 6028 GeneCards: WDR45B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,648,553 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	121,245,271 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right uterine tube; ; bronchial epithelial cell; ; Region I of hippocampus proper; ; germinal epithelium; ; lactiferous duct; ; palpebral conjunctiva; ; trachea; ; mucosa of urinary bladder; ; urethra;
	Top expressed in
	neural tube; ; ovary; ; mesencephalon; ; placenta; ; ganglionic eminence; ; heart; ; synovial joint; ; proximal tubule; ; hippocampus proper; ; liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding; protein binding; TSC1-TSC2 complex binding; lipid binding;
Cellular component	cytosol; extrinsic component of membrane; phagophore assembly site membrane; phagophore assembly site; lysosome;
Biological process	protein lipidation; protein localization to phagophore assembly site; autophagy of mitochondrion; autophagy of nucleus; autophagosome assembly; cellular response to starvation; autophagy;
	Sources:Amigo / QuickGO
Orthologs
	56270
	66840
	ENSG00000141580
	ENSMUSG00000025173
	Q5MNZ6
	Q9CR39
	NM_019613
	NM_025793
	NP_062559
	NP_080069
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.^[5]

Structure and function[edit]

WIPI-3 is a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein–protein interactions, and a conserved motif for interaction with phospholipids.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141580 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025173 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: WDR45-like".

Further reading[edit]

Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Jeffries TR, Dove SK, Michell RH, Parker PJ (2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
Proikas-Cezanne T, Waddell S, Gaugel A, et al. (2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141580 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025173 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WDR45-like".

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Structure and function[edit]

See also[edit]

References[edit]

Further reading[edit]